Exploration of the Activity of DNA Located Outside of Cellular Nucleus to Amplify Inflammation in Inflammatory Bowel Disease in Children Through Biological Pathway Cyclic GMP-AMP Synthase (cGAS) - Stimulator of Interferon Genes (STING) (ROXANE)
Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis
About this trial
This is an interventional health services research trial for Inflammatory Bowel Diseases focused on measuring Inflammatory Bowel disease, Crohn disease, Ulcerative colitis, cell-free DNA, cGAS, STING, Child, intestinal inflammation
Eligibility Criteria
Inclusion Criteria: Participants aged from 6 years inclusive to 17 years inclusive Boys and girls Presenting an IBD or suspicion of IBD Requiring a colonoscopy for diagnosis or follow-up or other reason (abdominal pain, diarrhoea, rectal bleeding, weight loss) not confirming the diagnosis of Crohn's disease or Ulcerative Colitis Active IBD if: CD: PCDAI score >5 and CRP>20mg/L and faecal calprotectin> 400 µg/g UC: PUCAI score>10 and faecal calprotectin>250 µg/g IBD in remission if: CD: PCDAI score<5 and CRP<20mg/L and faecal calprotectin<400 µg/g UC: PUCAI score <10 and faecal calprotectin < 250 µg/g Patients and their parents who gave their consent to participate in the study Exclusion Criteria: Refusal of the participant and/or one of his two parents Body weight less than or equal to 20 kg Blood hemoglobin level less than or equal to 9 g/dl Refusal or contraindication to general anesthesia Co-existing severe chronic pathology and/or treatment that could interfere with the results of the study; example: trisomy 21, treatment with growth hormone etc. Protected person (under guardianship or curatorship) Person under legal protection Person not affiliated to a social security scheme Pregnant or breastfeeding woman
Sites / Locations
- CHR OrléansRecruiting
Arms of the Study
Arm 1
Other
Patients with samples
Blood and fecal samples, and colonic biopsies will be analysed and compared between 3 groups of participants :1/ Active IBD; 2/Inactive IBD; 3/Controls "non-IBD".