Postextubation Use of Noninvasive Respiratory Support in Severely Obese Patients
Obesity, Morbid, Extubation Failure
About this trial
This is an interventional prevention trial for Obesity, Morbid
Eligibility Criteria
Inclusion Criteria: Adult, age ≥ 18 years old Receiving invasive mechanical ventilation for ≥24 hours BMI ≥40 kg/m2 Undergoing planned extubation per treating team Arterial pH ≥7.35 or venous pH ≥ 7.31 within 30 mins of spontaneous breathing trial (SBT) Exclusion Criteria: Pregnant Use of extra-corporeal membrane oxygenation Chronic tracheostomy in place Unplanned or accidental extubation Terminal/compassionate extubation Contraindication to NIV use Intubated for neurological reasons or for airway protection (stroke, intracerebral hemorrhage, intraventricular hemorrhage) Intubated because of an acute exacerbation of COPD Underlying neuromuscular disease No reintubation requested by patient/family Documented/known history of chronic hypercapnic respiratory failure on home NIV (including bilevel PAP). Enrolled in any other outcome study Treating clinician feels that HFNC or NIV are either mandatory or contraindicated for a given patient
Sites / Locations
- Rush University Medical CenterRecruiting
- Hospital Civil Fray Antonio AlcaldeRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Intervention Group (NIV with HFNC)
Control Group (HFNC alone)
Patients randomized to the intervention group will receive NIV alternating with HFNC for 24 hours after extubation
Patients randomized to the intervention group will receive HFNC only for 24 hours after extubation