Triple vs High Dose Inhaled CORticosteroids (TRICORDA)
Asthma
About this trial
This is an interventional treatment trial for Asthma focused on measuring Wheezing, Dyspnoea, Cough
Eligibility Criteria
Inclusion Criteria: Patients between 18 and 80 years of age diagnosed of uncontrolled asthma. T2 high asthma: > 300 cels/mm3 blood Eos (current value) or 150 cels/mm3 blood Eos (current value) and a historical value ≥ 300 cels/mm3 or FENO ≥ 25 ppb (current value). Uncontrolled asthma, this is, ACT <20 and/or > 1 of an exacerbation in the last 12 months, despite treatment with ICS/LABA at medium dose. Written informed consent. Exclusion Criteria: Patients who refuse to sign the informed consent form. Medical situation that prevents the collection of study information. Diagnosis of severe uncontrolled asthma established with criteria other than those established (ACT <20 and/or > 1 exacerbation in the last 12 months, despite treatment with ICS / LABA at medium dose). Medical or administrative situation that prevents the patient from following up to a minimum of 52 weeks. Treatment with high dose ICS/LABA, LAMA, systemic corticosteroid, azithromycin, monoclonal antibody.
Sites / Locations
- Hospital Comarcal de Inca - TramuntanaRecruiting
- Hospital Universitario Son EspasesRecruiting
- Hospital Universitario de CrucesRecruiting
- Hospital Universitario Galdakao-UsansoloRecruiting
- Hospital Universitario De JerezRecruiting
- Hospital Universitario de NavarraRecruiting
- Hospital de SaguntoRecruiting
- Hospital Universitario de A CoruñaRecruiting
- Hospital General Universitario Dr. Balmis de AlicanteRecruiting
- Hospital de la Santa Creu i Sant PauRecruiting
- Hospital Universitario Virgen de las NievesRecruiting
- Hospital Universitario Clínico San CecilioRecruiting
- Hospital Universitario Lucus AugustiRecruiting
- Hospital Universitario Ramón y CajalRecruiting
- Hospital Clínico Universitario de SalamancaRecruiting
- Hospital Universitario Doctor PesetRecruiting
- Hospital Costa del SolRecruiting
Arms of the Study
Arm 1
Arm 2
Active Comparator
Active Comparator
Triple treatment with medium doses of CSI/LABA/LA
Treatment with high doses of CSI/LABA
Medium-dose inhaled triple therapy of inhaled corticosteroid: IC, long-acting beta-agonist: LABA and anticholinergic: LAMA
High doses of of inhaled corticosteroid: IC and long-acting beta-agonist: LABA