Improved Muscle Metabolism by Combination of Muscle Activation and Protein Substitution ( IMEMPRO )
ICU Acquired Weakness, Muscle Atrophy, Energy Malnutrition Protein
About this trial
This is an interventional prevention trial for ICU Acquired Weakness focused on measuring Early Mobilization and high-protein nutrition
Eligibility Criteria
Inclusion Criteria: critically ill adults (≥ 18 years of age) newly admitted to the ICU (<48h) mechanically ventilated, expected to remain for at least 72h enteral nutrition is feasible Exclusion Criteria: a BMI > 30 expected death or withdrawal of life-sustaining treatments prior neuromuscular disease (e.g. paresis, myopathies, neuropathies) injury or disease preventing neuromuscular electrical stimulation or early mobilization (e.g., elevated intracranial pressure, unstable spine) a pacemaker or other electronic implant allergy to components of NMES adhesive have been dependent during activities of daily living prior to the hospital admission a language barrier
Sites / Locations
- Klinikum rechts der Isar, School of Medicine, Technical Universtity of Munich
- Charité - Universitätsmedizin BerlinRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
No Intervention
Intervention
Control Group
High protein substitution plus NMES and EM
Nutrition and mobilization are carried out according to standard of care.