The Role of Glucocorticoids to Maintain Energy Homeostasis During Starvation (Gluco-Starve)
Glucocorticoid Effect
About this trial
This is an interventional prevention trial for Glucocorticoid Effect focused on measuring cortisol, glucocorticoids, starvation, caloric restriction, fasting
Eligibility Criteria
Inclusion Criteria: BMI 18.5 - 27 kg/m2 Weight stability for 6 months prior to the trial (+/- 2kg) Exclusion Criteria: Previous medical history for any chronic condition in the last three months, active disease or abnormal physical examination as verified by a qualified physician. Casual smoking (>6 cigarettes per day) Frequent, heavy alcohol consumption (>30g/day) Frequent, heavy caffeine consumption (>4 caffeinated drinks/day) Regular physical exercise (>4hrs per week) Shift workers Participation in an investigational drug trial within the past two months Intake of any drugs (prescribed, over the counter or recreational), within 48 hours of the study initiation Intake of any steroids (including topical or inhaler) six month prior to the study Known allergy to metyrapone or hydrocortisone Inability or unwillingness to provide informed consent
Sites / Locations
- University Hospital BaselRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Placebo Comparator
Metyrapone And Hydrocortisone
Placebo
During one of the study periods, subjects receive hydrocortisone 19.9 mg/d subcutaneously via a pump in a pulsed fashion (eight times/day) and metyrapone per os (starting with a dose of 500 mg/d, then the dose will be increased the next days until 3000mg/d is achieved).
During the other study period, subjects receive placebo (0,9% NaCl solution) 19.9 mg/d subcutaneously via a pump in a pulsed fashion and the same dose of placebo tablets p.o instead of metyrapone