Moderate Alcohol Consumption and Heart Function in Patients With a Recent Myocardial Infarction (Moderate)

Inclusion Criteria: Hospitalization for acute ST-elevation MI (STEMI) or non ST-elevation MI (NSTEMI) within 365 days prior to screening Men and women aged ≥18 years who are capable and willing to provide consent ECG ischemic changes, such as persistent or dynamic ST-segment deviation Evidence of positive high-sensitive troponin Confirmation of coronary heart disease aetiology by angiography Capacity to complete study visits with strict adherence to the protocol assignment Self-reported average alcohol consumption of between 4 and 28 standard units per week in the 12 months prior to the index hospitalization. Exclusion Criteria: High alcohol consumption, defined as an average of >21 alcoholic standard units/week in the 12 months prior to the index hospitalization Alcohol use disorder (AUDIT score >20 at screening) History of alcohol or substance abuse Naïve to alcohol consumption Light alcohol consumption (<4 standard units by week) Prior severe heart failure (NYHA III-IV) Severe LV dysfunction at screening (<40%) History of gastric ulcer or gastro-intestinal bleeding Serious chronic liver disease or liver test elevation (> 3 times upper limit normal range) Personal history of any colon or liver cancer Any active malignancy (less than 5 years or ongoing treatment) Estimated glomerular filtration rate 15 ml/min/1.73m² or end-stage renal disease Any medication (investigator's discretion) making study participation impractical or precluding required follow-up History of organ transplant Participation in another trial testing intervention on similar CV outcomes (investigator's discretion) Any medical, geographic, or social factor making study participation impractical or precluding required follow-up.