CAlgary SAlt for POTS (CASA-POTS)
Postural Orthostatic Tachycardia Syndrome
About this trial
This is an interventional treatment trial for Postural Orthostatic Tachycardia Syndrome focused on measuring Sodium, Salt, Treatment
Eligibility Criteria
Inclusion Criteria: Physician Diagnosis of POTS as defined by the CCS Consensus Statement and as follows: Sustained, excessive orthostatic tachycardia ≥ 30 bpm within 10 minutes standing. Absence of orthostatic hypotension (>20/10 mmHg decrease) within 3 minutes standing. Chronic orthostatic symptoms that improve with recumbence. Age 18-60 years old. Ability to attend the Calgary Autonomic Research Clinic in Calgary. Resident of Canada Exclusion Criteria: Overt cause for postural tachycardia (i.e., acute dehydration, thyroid disease) Participants with somatization or severe anxiety symptoms will be excluded Pregnant (self-reported) Underlying causes of tachycardia including acute hypovolemia, endocrinopathy, anemia, anxiety, medication effects, recreational drug effects, and prolonged bedrest. Other factors which in the investigator's opinion would prevent the participant from completing the protocol, including poor compliance during previous studies Fludrocortisone use (due to effects on renal Na+ handling) Patients who have received IV saline in the 2 months preceding the study or who plan to receive it during the course of the study
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Experimental
Placebo Comparator
Moderate Dietary Salt Plus Additional Salt
Moderate Dietary Salt Alone
6 grams of salt in slow release capsules combined with 6 grams of salt in the diet.
6 grams of microcrystalline cellulose in slow release capsules combined with 6 grams of salt in the diet.