C-Protein in Fatigue and Aging
Aging, Muscle Atrophy or Weakness, Sarcopenia in Elderly
About this trial
This is an interventional basic science trial for Aging focused on measuring muscle, aging, elderly, myosin, protein, sarcomere, exercise, function, atrophy, contractile, strength, balance, mobility, MyBP-C, fiber, biopsy, skeletal muscle, fatigue
Eligibility Criteria
Inclusion Criteria: Adults between the ages 18-35 or 65-80 years Healthy by self-report Willing to participate in all aspects of the study design including muscle biopsy, unilateral exercise, and physical activity monitoring Fluent in English (due to lack of translation services, it is not practical to conduct the study using a language other than English). Exclusion Criteria: Orthopaedic limitation (severe knee osteoarthritis, prior joint replacement, etc.). Volunteer has dementia or related mental issues that potentially put the subject at risk as determined by prior diagnosis. Volunteer has known untreated endocrine disease (hypo/hyper thyroidism, Addison's Disease or Cushing's syndrome, etc.) Volunteer has untreated/poorly-controlled hypertension (stage 2, per American College of Cardiology [>140/90 mmHg]). Volunteer has significant heart, liver, kidney or respiratory disease. Volunteer has diabetes (insulin dependent or non-insulin dependent). Volunteer has known coagulopathies. Volunteer has taken anabolic steroids in the prior six months. Volunteer has received treatment for cancer (other than effective Mohs Surgery for successful removal of basal cell or squamous cell carcinomas) Unexpected weight loss >5kg is last 12 months Volunteer is an active smoker or quit within the last year. Volunteer has known current alcohol or drug use disorder (AUD; defined as binge drinking of >4 days in the last month. Binge drinking is >5 drinks for men and >4 drinks for women, per occasion). Or, if a volunteer reports drinking in excess of "low risk" per NIAAA (>7 drinks/week for men and >3 drinks/day for women and >14 drinks/week and >4 drinks/day). Volunteer has a diagnosed neuromuscular disorder. Volunteer has allergy to lidocaine.
Sites / Locations
- University of OregonRecruiting
Arms of the Study
Arm 1
Experimental
Fatigue
Volunteers will perform one-legged knee extension exercise until fatigue while seated on an ergometer. Volunteers will then undergo bilateral skeletal muscle biopsies of the vastus lateralis muscle in their thigh.