Efficacy and Mechanism of Repetitive Transcranial Magnetic Stimulation in Children With Autism Spectrum Disorders
Autism Spectrum Disorder
About this trial
This is an interventional treatment trial for Autism Spectrum Disorder focused on measuring Repetitive Transcranial Magnetic Stimulation(rTMS), Autism Spectrum Disorder, Intervention, Social Deficits, Language Function, Children
Eligibility Criteria
Inclusion Criteria: Children aged 4-10 years old Meet the diagnostic criteria for ASD of the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) ASD Diagnosis confirmed by the Autism Diagnostic Observation Schedule (ADOS) or Autism Diagnostic Interview, Revised (ADI-R) IQ of 50 or above Provide written informed consents Exclusion Criteria: With metal implants in the body History of epilepsy or other neurological disease Require surgical treatment due to structural abnormalities indicated by brain MRI Diagnosed with genetic and chromosomal abnormalities With psychiatric/mental disorder (e.g., very early-onset schizophrenia) other than ASD Suffer from serious heart disease and/or severe hearing impairment Intracranial hypertension Participating in other clinical trials Participants who received other interventions within 4 weeks prior to enrollment.
Sites / Locations
- Henan Children's HospitalRecruiting
- Qilu Hospital of Shandong UniversityRecruiting
- Xinhua Hospital, Shanghai Jiao Tong University School of MedicineRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Sham Comparator
Intervention Group
Sham Group
participants in intervention group will receive accelerated continuous theta-burst stimulation (a-cTBS) on the left primary motor cortex (M1) for 5 consecutive days.
The sham group will be stimulated with a pseudo-stimulation coil, which emitted sounds with the same intensity, rhythm and vibratory sensation as the real stimulation, and the intervention target, duration and frequency are the same as the real intervention group.