Improving Mobility and Function Following Transfemoral Amputation: A Novel Approach to Reverse Volumetric Muscle Loss
Traumatic Amputation of Lower Extremity
About this trial
This is an interventional basic science trial for Traumatic Amputation of Lower Extremity
Eligibility Criteria
Inclusion Criteria: At least 18 years old History of lower limb unilateral transfemoral amputation. At least two years post lower limb amputation Able to ambulate independently without the use of aids (i.e., walking cane). Able to walk at least 10 minutes continuously without stopping. Has a safe residuum with no open wounds on either the residual or intact limb. Has a prosthetic limb with materials that are sound and safe to withstand the mobility requirements of the study. Exclusion Criteria: Younger than 18 years old. Inability to give informed consent. Neurological disorder that affects gait. Participants with significant metal (greater than one orthopaedic screw) in either the residual limb or the sound/intact limb Participants who begin taking medications or change dosage of medications that could affect gait, balance, and cardiovascular function during the course of the study. Currently pregnant (or intend to become pregnant while participating in study). History of any condition where fatiguing contractions or resisted leg contractions are contraindicated. Blood clots in the leg, or any condition in which compression of the thigh or transient ischemia is contraindicated (e.g. open wounds in the leg). History of uncontrolled hypertension. History of heart failure. Head injury within the previous 6 months. Seizure disorder. History of vascular disease. History of thrombosis. History of sickle cell trait. History of genetic disease
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Active Comparator
Sham Comparator
Ischemic Preconditioning at High Pressure
Ischemic Preconditioning at Low Pressure
In this arm, the participant will receive ischemic preconditioning (a blood pressure cuff on the intact limb) inflated to 225mmHg for 5 minutes followed by 5 minutes of reperfusion on a cycle for a total of 50 minutes. This will be completed every other day for 7 session (14 days).
In this arm, the participant will receive ischemic preconditioning (a blood pressure cuff on the intact limb) inflated to 25mmHg for 5 minutes followed by 5 minutes of reperfusion on a cycle for a total of 50 minutes. This will be completed every other day for 7 session (14 days).