Initial Staging of Lobular Breast Carcinoma: Head to Head Comparison of 68Ga-FAPI-46 and 18F-FDG PET/CT (GALILEE)
Lobular Breast Carcinoma
About this trial
This is an interventional diagnostic trial for Lobular Breast Carcinoma focused on measuring 68Ga-FAPI-46, 18F-FDG PET, FAPα, staging
Eligibility Criteria
Inclusion Criteria: Age greater than or equal to 18 years ECOG from 0 to 2 Histological diagnosis of Lobular Carcinoma of the breast based on a breast biopsy Patient naïve to any treatment for lobular breast carcinoma Women of childbearing age should have an adequate method of contraception Patient having voluntarily accepted to participate in the study and signed the informed consent Minimum tumor stage IIA Sufficient histological material in the biopsy or the surgical specimen, if the biopsy is insufficient Exclusion Criteria: PET scan contraindications: severe claustrophobia, unbalanced diabetes during 18F-FDG PET scans (fasting capillary blood sugar ≥ 11 mmol) Hormone therapy started 18F-FDG PET scan > 21 days Pregnant women, parturients and nursing mothers Persons deprived of liberty by a judicial or administrative decision Persons admitted to a health or social establishment for purposes other than research Adults who are the subject of a legal protection measure or who are unable to express their consent
Sites / Locations
- Centre Hospitalier Princesse GraceRecruiting
Arms of the Study
Arm 1
Experimental
68Ga-FAPI-46 PET scan + 18-FDG PET scan