A Study of LY3502970 in Participants With Normal and Impaired Renal Function
Renal Insufficiency, Healthy
About this trial
This is an interventional basic science trial for Renal Insufficiency
Eligibility Criteria
Inclusion Criteria: Have a body mass index within the range 18.5 to 42.0 kilograms per meter squared (kg/m²), inclusive. Men and women who agree to use highly effective or effective methods of contraception may participate in this trial. Participants with Normal Renal Function: Healthy males or females as determined by medical history, physical examination, and other screening procedures, with normal renal function. Have estimated glomerular filtration rate (eGFR) of greater than or equal to 90 milliliter per minute (mL/min) Participants with Renal Impairment: Severe renal impairment: Have eGFR of 15 to 29 mL/min and not requiring hemodialysis. ESRD: Participants who have been on a stable hemodialysis schedule for at least 3 months prior to planned dosing. Exclusion Criteria: Have a current, functioning organ transplant. Non-functional renal allografts may be allowed. Regularly use known drugs of abuse or show positive findings on urinary drug screen that are not otherwise explained by permitted concomitant medications. Have known allergies to LY3502970, related compounds, or any components of the formulation, or history of severe atopy. Are lactating, pregnant, or intend to become pregnant, or to breastfeed during the study. Have a history or presence of chronic or acute pancreatitis Participants with Renal Impairment: Have hemoglobin <8.5 g/dL. Participants with Type 2 Diabetes Mellitus if they have taken any Glucagon-like Peptide-1 Receptor Agonists (GLP1-RA) or a Dipeptidyl Peptidase 4 (DPP4) inhibitor in the past 6 weeks or 5 half-lives prior to dosing, whichever is longer, prior to dosing on Day 1
Sites / Locations
- Clinical Pharmacology of MiamiRecruiting
- Advanced Pharma Clinical ResearchRecruiting
- Orlando Clinical Research CenterRecruiting
- Alliance For multispecialty Research, LLCRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Experimental
Experimental
LY3502970 (Control)
LY3502970 (Severe Renal Impairment)
LY3502970 (End-Stage Renal Disease)
LY3502970 administered orally to participants with normal renal function
LY3502970 administered orally to participants with severe renal impairment
LY3502970 administered orally to participants with end-stage renal disease (ESRD)