Metabolism in the Human Brain Following Consumption of a Keto-ester in Alcohol Use Disorder (AUD) With Proton Magnetic Resonance Spectroscopic Imaging (MRSI)
BHB Transport, Alcohol Use Disorder
About this trial
This is an interventional basic science trial for BHB Transport focused on measuring BHB, AUD
Eligibility Criteria
Inclusion Criteria: For AUD patients: individuals assessed to be with mild to - medium severity according to the DSM-5 criteria. For non-dependent heavy at-risk drinkers: must be Individuals who consume more than 14 drinks per week for men or more than 8 drinks per week for women, for at least the last 2 months. For healthy controls: must be light drinkers not dependent on alcohol, who consume fewer than 2 drinks per week for at least the last 6 months. English speaking Can read and understand a study the consent form Exclusion Criteria: Non-English speaking Unable to read and understand the consent form History of alcohol withdrawal in the last 12 months. This will reduce chances of a volunteer having withdrawal symptoms in the middle of the experiment. Participants with a history of psychiatric conditions (that include PTSD, schizophrenia, and bipolar disorders), or a history of neurological conditions Women who test positive on a pregnancy test collected on either the screening visit or day of the study. Healthy subjects identified with substance use with the exception of tobacco and alcohol will be excluded. AC subjects identified with substance use, with the exception of tobacco, alcohol, and mild cannabis use disorder (based on the DSM-5 criteria during the medical history) in the last 6 months, will be excluded. Persons unable to refrain from alcohol use for 48 hours and undergo a 10-hour fast prior to the study
Sites / Locations
- The Anlyan Center (TAC)Recruiting
Arms of the Study
Arm 1
Arm 2
Other
Other
Alcohol consumer (AC) participants
Healthy participants
Adult volunteers who are alcohol consumers drawn from both an outpatient population and recruited heavy drinkers from the community.
Healthy adult volunteers who are not dependent on alcohol.