Persea Americana for Total Health (PATH)-2 (PATH-2)
Overweight and Obesity
About this trial
This is an interventional basic science trial for Overweight and Obesity focused on measuring Avocado, Gastrointestinal microbiome, Bile acid profile, Inflammation, Thinking, Glycemia
Eligibility Criteria
Inclusion Criteria: Participants must be between the ages of 25 and 74 years old BMI ≥ 25 kg/m2 Ability to drop off fecal sample within 15 minutes of defecation 20/20 or corrected vision Exclusion Criteria: Avocado allergy or intolerance Food allergies or intolerances Prior diagnosis of liver or gastrointestinal disease (primary biliary cirrhosis or gallbladder disease, chronic constipation, diarrhea, Crohn's disease, celiac disease, ulcerative colitis, irritable bowel syndrome, diverticulosis, stomach or duodenal ulcers), diabetes, hepatitis, HIV, or cancer Women that are pregnant, have given birth in the previous 12 months or are lactating Individuals that smoke, use tobacco, abuse drugs, or consume > 2 alcoholic beverages per day. > 5% weight change in the past month or > 10% change in the past six months Oral antibiotics during the previous 6 weeks. Currently taking lipid-lowering medications, oral hypoglycemic agents, or insulin. History of malabsorptive or restrictive bariatric surgeries (e.g., gastric bypass, sleeve gastrectomy, adjustable gastric band) or gall bladder removal surgery. Are unable to consume the experimental meals/snacks. Allergic to latex Concurrent enrollment in another dietary, exercise, or medication study
Sites / Locations
- University of Illinois, Urbana ChampaignRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Active Comparator
Sham Comparator
Avocado
Fiber + Oil
Standard American Diet
The experimental treatment will contain an avocado. Avocados will be consumed daily for 4 weeks.
The active comparator will have a snack that mimics the fiber and fatty acid composition found in avocados and will be consumed daily for 4 weeks.
The sham comparator contains foods and beverages of a standard American diet and will be consumed daily for 4 weeks.