ARC Therapy to Restore Hemodynamic Stability and Trunk Control in People With Spinal Cord Injury (HemON-NL)

Inclusion Criteria: 18 years of age or older Must provide and sign the Informed Consent prior to any study-related procedures Traumatic Spinal Cord Injury Spinal cord injury lesion level between C3 and T6 (inclusive) AIS- A, B, C or D SCI ≥ 1month Confirmed orthostatic hypotension Stable medical, physical and psychological condition as considered by the investigators Able to understand and interact with the study team in Dutch or English Agrees to comply in good faith with all conditions of the study and to attend all scheduled appointments In case participants need continuous support from a personal caregiver in daily life, then the presence of their caregiver during the visits to the study site is needed, including independent transport (not dependent on a cab) Exclusion Criteria: Diseases and conditions that would increase the morbidity and mortality of spinal cord injury surgery Diseases and conditions that would require regular MRI The inability to perform an MRI due to metal, magnetic or electrical device in the body (e.g. oral implant with magnet, mtal splinter, neurostimulator, artificial heart valve, clips, stents...) as assessed by the MRI form of Sint Maartenskliniek The inability to withhold antiplatelet/anticoagulation agents perioperatively History of myocardial infarction or cerebrovascular event within the past 6 months Other conditions that would make the subject unable to participate in testing in the judgement of the investigators Clinically significant mental illness in the judgement of the investigators Botulinum toxin non-vesical and vesical injections in the previous 3 months before the enrolment Presence of significant pressure ulcers Recurrent urinary tract infection refractory to antibiotics Presence of indwelling baclofen (e.g. intrathecal baclofen pump) or insulin pump Women who are pregnant (pregnancy test obligatory for woman of childbearing potential) or breast feeding Lack of safe contraception for women of childbearing capacity Intention to become pregnant during the course of the study, Other clinically significant concomitant disease states (e.g., renal failure, hepatic dysfunction, cardiovascular disease, etc.) Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, or dementia of the participant Participation in another study with investigational drug within the 30 days preceding and during the present study Enrolment of the investigator, his/her family members, employees, and other dependent persons