Role of NADPH Oxidase in Microvascular Dysfunction Following GDM
Gestational Diabetes, Oxidative Stress, Vascular Endothelial Function
About this trial
This is an interventional basic science trial for Gestational Diabetes focused on measuring gestational diabetes, postpartum, vascular
Eligibility Criteria
INCLUSION CRITERIA: 18 years or older pregnant within 5 years of the study visit had gestational diabetes diagnosed by their obstetrician and confirmed according to the American College of Obstetricians and Gynecologists criteria for gestational diabetes. or without a history of gestational diabetes EXCLUSION CRITERIA: skin diseases current tobacco or electronic cigarette/vape pen use, diagnosed or suspected hepatic or metabolic disease including diabetes, statin or other cholesterol-lowering medication, current antihypertensive medication, history of preeclampsia or gestational hypertension, current pregnancy, body mass index <18.5 kg/m2, allergy to materials used during the experiment.(e.g. latex), known allergies to study drugs
Sites / Locations
- University of IowaRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Placebo Comparator
Experimental
Experimental
Experimental
local lactated Ringer's perfusion
local apocynin perfusion
local L-NAME perfusion
local apocynin + L-NAME perfusion
lactated Ringer's is perfused through the microdialysis fiber to serve as the vehicle control
local apocynin is perfused through the microdialysis fiber to serve as the NADPH oxidase inhibited experimental treatment
local L-NAME is perfused through the microdialysis fiber to inhibit nitric oxide synthase
local apocynin and L-NAME are perfused through the microdialysis fiber for dual inhibition of NADPH oxidase and nitric oxide synthase