PASCA-MM Study. Impact of the PASCA (PArcours de Santé au Cours du CAncer) Program on Complications Associated With Multiple Myeloma and/or Its Treatments in the Context of a First Hematopoietic Stem Cell Autograft, in Adults Aged 18 to 70. (PASCA -MM)
Multiple Myeloma, Complication
About this trial
This is an interventional prevention trial for Multiple Myeloma focused on measuring Multiple Myeloma, Complications, Detection, Intervention, Autologous stem cell transplant, Randomized controlled trials
Eligibility Criteria
Inclusion Criteria: Age ≥ 18 years old and ≤ 70 years old. Patient treated in an investigation center. Symptomatic multiple myeloma eligible for autologous hematopoietic stem cell transplantation (HSCT). In stringent complete response, complete response, very good complete response, or partial before HSCT. First induction-type treatment (Isa-KRD/dara-VRD/dara-VTD/VRD/VTD), intensification therapy with melphalan, HSCT, consolidation, maintenance including at least one drug immunomodulator. ECOG performance status WHO ≤ 2. No history or coexistence of other primary cancer apart from basal cell cancer cutaneous Able to understand, read and write French. Having signed and dated the informed consent. Exclusion Criteria: Unable to be monitored for medical, social, family, geographical or psychological, throughout the duration of the study. Deprived of liberty by court or administrative decision. Not affiliated with a health insurance plan. Not having declared an attending physician. Not domiciled in the Auvergne-Rhône-Alpes region or in the Saône-et-Loire department. Not available and/or not willing to participate in the project for the entire duration of the study. Pregnant women, breastfeeding women, people in emergency situations, people incapable of personally giving their consent including adults under guardianship
Sites / Locations
- Centre Léon Bérard
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Intervention group
Control group
For both the 7 complications of interest (primary objective) and the 13 secondary complications (secondary objective), specific and proactive referrals will be made systematically after each detection visit according to the level of risk, estimated on the basis of decision trees (management guide) and via the dedicated PASCA network of healthcare professionals, to initiate early treatment and follow-up where necessary.
For both the 7 complications of interest (primary objective) and the 13 secondary complications (secondary objective): all the data from each detection visit will be sent to the referring forwarded to the referring onco-haematologists, so that they can initiate their own management.