Vertebral Bone Marrow Clot for Spinal Surgery
Degenerative Spine Diseases
About this trial
This is an interventional treatment trial for Degenerative Spine Diseases focused on measuring Spine, Spinal fusion, Degenerative diseases, Vertebral bone marrow, Clot
Eligibility Criteria
Inclusion Criteria: degenerative spinal disorders (based radiological diagnosis) posterior spinal stabilization ≤ 5 levels age between 18-80 years at the time of surgery Exclusion Criteria: HIV HBV HCV coagulations disorders pregnant or breast-feeding women cancer infections previous spinal surgery radio- chemotherapy myeloproliferative disease chronic steroid medication, thyroxin, immunodepression
Sites / Locations
- Istituto Ortopedico RizzoliRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Experimental group - vertebral bone marrow (vBMA) clot
Control - bone allograft chips
Bone allograft chips will be obtained from Istituto Ortopedico Rizzoli while vBMA will be harvested from each patient vertebral pedicle with the preparation of the site for pedicle screw insertion during spinal surgery. After the positioning of pedicle screws, the decompression of the cauda and nerve roots will be achieved with a hemilaminectomy and foraminotomy. vBMA clot associated with bone allograft chips will be opposed on the hemi-laminae and transvers process on the contralateral side of the hemilaminectomy. On the hemilaminectomy side, foramino-arthrectomy will be performed to insert the interbody fusion cage if necessary. After aspiration, the vBMA will be clotted and used for surgical procedure. vBMA clot associated to bone allograft chips will be applied on each side of the vertebra according to the number of segments to be fused.
Bone allograft chips will be obtained from Istituto Ortopedico Rizzoli. In detail, conventional posterior approach for lumbar SF will be performed. After the positioning of pedicle screws, the decompression of the cauda and nerve roots will be achieved with a hemilaminectomy and foraminotomy. Bone allograft chips alone will be opposed on the hemi-laminae and transvers process on the contralateral side of the hemilaminectomy. On the hemilaminectomy side, foramino-arthrectomy will be performed to insert the interbody fusion cage if necessary.