Prevention of Post-ERCP Pancreatitis by Indomethacin vs Diclofenac
Post-ERCP Acute Pancreatitis, NSAIDs, Indomethacin
About this trial
This is an interventional prevention trial for Post-ERCP Acute Pancreatitis
Eligibility Criteria
Inclusion Criteria: 18-90 years old patients planned to undergo ERCP Exclusion Criteria: Allergy to NSAIDs The administration of NSAIDs within 7 days Not suitable for NSAIDs administration (gastrointestinal hemorrhage within 4 weeks, renal dysfunction [Cr >1.4mg/dl=120umol/l]; presence of coagulopathy before the procedure) Previous biliary sphincterotomy and papillary large balloon dilation Acute pancreatitis within 3 days before ERCP Hemodynamical instability Pregnancy or lactation Unable to give informed consent
Sites / Locations
- Department of gastroenterology, Second Affiliated Hospital of Chongqing Medical UniversityRecruiting
- Department of Gastroenterology, Fujian Medical University Xiamen Humanity HospitalRecruiting
- Department of Gastroenterology, The 980th Hospital of the PLA Joint Logistics Support ForceRecruiting
- Department of Gastroenterology, Huaihe Hospital of Henan UniversityRecruiting
- Department of Hepatobiliary Surgery, General Hospital of Ningxia Medical UniversityRecruiting
- The Second Affiliated Hospital of Xi'an Jiaotong UniversityRecruiting
- Department of Gastroenterology,The 986th Hospital of Xijing HospitalRecruiting
- Xijing Hospital of Digestive Diseases, Air Force Military Medical University, ChinaRecruiting
- Deparment of hepatobiliary surgery, The First Affiliated Hospital Of Xi'an Jiaotong UniversityRecruiting
- Department of Gastroenterology and Endoscopy, Department of Gastroenterology and EndoscopyThe Third Affiliated Hospital of Naval Military Medical UniversityRecruiting
- Department of Gastroenterology, General Hospital of Xinjiang Military RegionRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
diclofenac group
Indomethacin group
Patients without contraindications in diclofenac group received 100mg rectal diclofenac 30 mins before ERCP procedure.
Patients without contraindications in indomethacin group received 100mg rectal indomethacin 30 mins before ERCP procedure.