Manufacturing of Allogeneic Adipose Tissue-derived Mesenchymal Stromal Cells for Treatment of Severe Systemic Sclerosis (Pre_MSC-AT-SSc)
Mesenchymal Stromal Cell, Systemic Sclerosis
About this trial
This is an interventional other trial for Mesenchymal Stromal Cell
Eligibility Criteria
Inclusion Criteria: Age ≥ 18 and ≤ 55 years BMI <30 Non-smoker Admission for a pre-scheduled plastic surgery intervention liposuction or lipo-aspiration in the abdominal wall under general anesthesia Written consent Affiliated to a social security Exclusion Criteria: Weight < 50 kg Positive viral serology : Hepatitis B Virus (HBV), Hepatitis C Virus (HCV), Human Immunodeficiency Virus (HIV), Hepatitis E Virus (HEV), syphilis, Human T Lymphotropic virus (HTLV), active infection with IgM+ for toxoplasmosis, Epsiten Barr Virus (EBV), Cytomegalovirus (CMV) Active generalized infection (viral, parasitic, tuberculosis, leprosy...) Significant comorbidities according to donor health history or existing risk factors for viral infections within the past 12 months: Multiple sexual partners between the donor or his or her usual partner Intravenous addiction to the donor or regular partner Accident of exposure to blood or derivatives suspected of being contaminated Uncontrolled hypertension Human dura mater transplant Surgical history of the central nervous system Dementia or neurological disease that may evoke subacute spongiform encephalopathy Family history as part of subacute spongiform encephalopathy Hematological malignancies Active or any past history of cancer History of chemotherapy or irradiation Systemic or autoimmune disease Multiple adenopathy, splenomegaly, hepatomegaly Icterus Haemophilia Known insulin-dependent diabetes Treatment with extractive pituitary hormones (including growth hormones) Steroids therapy (for more than 5 days) in the past 3 months Lithium treatment Pregnancy Deprived of freedom
Sites / Locations
Arms of the Study
Arm 1
Other
Adults who are planned to undergo plastic surgery
Adults who are planned to undergo plastic surgery for abdominal liposuction or lipoaspiration under general anaesthetic for their own care and who are voluntary for fat donation to contribute to the study