Dose-escalating Trial With Allo-RevCAR01-T Cells in Combination With CD123 Target Module (R-TM123) for Participants With Selected Hematologic Malignancies Positive for CD123

Inclusion Criteria: Male or female participants, age ≥18 years. HLA type of participant must match at HLA B and C loci Participants with CD123+ AML (defined as ≥20% of leukemic cells expressing CD123 at any point in the course of disease) - Participants with MRD+ AML are eligible but must meet specific criteria Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1. Life expectancy of at least 3 months in the judgment of the investigator. Adequate renal and hepatic laboratory assessments: Adequate cardiac function Permanent venous access existing (e.g., port-system) or willing to have such a device inserted. Able to give written informed consent. Weight ≥45 kg. Negative pregnancy; routinely using a highly effective method of birth control Exclusion Criteria: Acute promyelocytic leukemia (t15;17). History of AML in the central nervous system. Bone marrow failure syndromes Cardiac disease: heart failure (New York Heart Association III or IV); unstable coronary artery disease, myocardial infarction, or serious cardiac ventricular arrhythmias requiring anti-arrhythmic therapy within the last 6 months prior to study entry. Active pulmonary disease with clinically relevant hypoxia Parkinson's disease or epilepsy. Stroke, seizure, or intracranial hemorrhage in the past 12 months. History or presence of disseminated intravascular coagulation (DIC) or thromboembolism within 3 months prior to start of treatment. Active infectious disease considered by investigator to be incompatible with protocol or being contraindications for lymphodepletion therapy Toxicity from prior anticancer treatment has not resolved to Grade ≤1 or baseline. Allogeneic stem cell transplantation within last 2 months or GvHD requiring immunosuppressive therapy. Vaccination with live viruses <2 weeks prior to lymphodepletion therapy. Major surgery within 28 days prior to start of R-TM123 infusion. Prior malignancy in the past 3 years or any malignancy requiring ongoing active therapy other than adjuvant endocrine therapy. Participants with resected or ablated tumors, such as basal cell carcinoma of skin, carcinoma-in-situ of the cervix, or other tumors considered cured by local treatment may be considered for the study with Sponsor approval. Treatment with any investigational drug substance or experimental therapy within 4 weeks or 5 half-lives (whichever is shorter) of the substance prior to lymphodepletion. Treatment with anti-leukemic therapy within 4 weeks or 5 half-lives (whichever is shorter) prior to lymphodepletion. Prior treatment with gene modified cell products. Use of checkpoint inhibitors within 5 half-lives of the specific drug. Autoimmune diseases requiring systemic steroids or other systemic immunosuppressants. Pregnant or breastfeeding women. Psychologic disorders with treatment modifications required within the last 3 months, drug and/or significant active alcohol abuse as per investigator's medical judgement. Depression or anxiety due to presence of the underlying malignancy may be exempted with Sponsor approval. History of human immunodeficiency virus (HIV) or active/chronic infection with hepatitis C virus (HCV) or hepatitis B virus (HBV). Presence of autoantibodies against lupus La protein (La)/ Sjögren syndrome type B antigen (SS-B) or presence or history of autoimmune diseases associated with such antibodies Known hypersensitivity to cellular component (Allo-RevCAR01-T) and/or TM (R-TM123) excipients or to compounds of the lymphodepletion therapy, tocilizumab, or corticosteroids. Evidence that the participant is not likely or able to follow the study protocol (e.g., lacking compliance) in the judgment of the investigator. Participant unable to understand the informed consent and possible consequences of the participation in the clinical trial in the judgement of the investigator.