Intra-arterial Albumin Infusion After Endovascular Therapy for Stroke Patients
Stroke, Acute Ischemic, Albumin, Endovascular Procedures
About this trial
This is an interventional treatment trial for Stroke, Acute Ischemic focused on measuring Acute Ischemic Stroke, Albumin, Endovascular Therapy, Large Vessel Occlusion
Eligibility Criteria
Inclusion Criteria: 1. AIS patients with anterior circulation due to large vessel occlusion; 2. Age between 18 and 80 years; 3. Baseline NIHSS score ≥ 6; 4 .Successful recanalization after thrombectomy (mTICI grade ≥ 2b); 5. Written informed consent provided by the patients or their legal relatives. . Exclusion Criteria: Upon admission, the patient's medical history and physical examination revealed manifestations indicative of congestive heart failure (CHF), such as jugular venous distention, the presence of a third heart sound, resting tachycardia at a rate of 100 beats per minute attributable to heart failure, hepatomegaly, and/or lower extremity edema attributable to heart failure or of unknown etiology; History of acute myocardial infarction within the preceding 3 months; The patient's medical history, electrocardiogram findings upon admission, or physical examination indicated the presence of second- or third-degree heart block or any arrhythmia associated with hemodynamic instability, as determined by the investigator's assessment; Acute or chronic renal failure with serum creatinine levels exceeding 2.0 mg/dL; Severe anemia characterized by a hematocrit below 32%; Computed tomography findings upon admission indicating the presence of any form of hemorrhage; Pregnancy status; Previous history of allergic reactions to albumin administration; Elevated blood pressure exceeding 185/110 mmHg when investigating the use of albumin administration; Presence of other potentially life-threatening medical conditions; Individuals with current chronic lung diseases, such as chronic obstructive pulmonary disease, bronchiectasis, or any other lung disorder that significantly impairs daily activities; 12. Individuals with known allergies to albumin.
Sites / Locations
- Tianjin Huanhu Hospital
Arms of the Study
Arm 1
Experimental
Intra-arterial albumin infusion