90Y Transarterial Radioembolization Versus Microwave Ablation in Small Hepatocellular Carcinoma With Hypoalbuminemia (REALM)
Carcinoma, Hepatocellular
About this trial
This is an interventional treatment trial for Carcinoma, Hepatocellular focused on measuring Yttrium-90, Hypoalbuminemia
Eligibility Criteria
Inclusion Criteria: HCC diagnosis according to the Liver Imaging - Reporting Data System (LI-RADS) Criteria as defined in the American Association for the Study of Liver Diseases 2018 HCC practice guidelines Eastern Cooperative Oncology Group score 0 - 1 Child-Pugh A - B Bilirubin < 2.5 mg/dL Creatinine < 2.0 mg/dL No prior liver-directed therapy or systemic therapy for HCC Solitary, unresectable HCC ≤ 3cm Albumin level < 3.4 g/dL at HCC diagnosis Tumor anatomical location and angiosome amendable to MWA and 90Y Exclusion Criteria: Pregnant women Concurrent malignancy
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Active Comparator
Active Comparator
Therasphere Transarterial Radioembolization
Microwave Ablation
Two-phase treatment including mapping angiogram with personalized dosimetry followed by complete treatment of the tumor angiosome with 90-Yittrium glass microsphere infusion.
Ablation performed with a high powered, gas cooled multi-antenna system targeting an ablative margin > 5mm.