Chronic Hepatitis B Patients With Concurrent MAFLD: Cohort Study and Exercise Intervention.
Chronic Hepatitis B, Non-alcoholic Fatty Liver Disease
About this trial
This is an interventional treatment trial for Chronic Hepatitis B focused on measuring Metabolic syndrome, Exercise intervention, Fatty liver, Chronic Hepatitis B, Gut microbiota
Eligibility Criteria
Inclusion Criteria: Age >18 years of age Either gender HBV treatment naïve Capable of taking exercise HBsAg positivity for >6 months Evidence of fatty liver in both abdominal ultrasonography and Fibroscan™(CAP>215) Exclusion Criteria: Age >70 years of age Evidence of liver cirrhosis Patients fulfilling reimbursement criteria for HBV treatment Evidence of severe cardiopulmonary diseases Evidence of serious hip or knee problems, incapable of taking exercise Evidence of liver decompensation Evidence of active HCV (positive for serum HCV RNA) or HIV infection (positive for anti-HCV) Clinical diagnosis of Alzheimer's Disease Thyroid disease
Sites / Locations
- National Taiwan University Hospital
Arms of the Study
Arm 1
Arm 2
Experimental
No Intervention
Exercise group
Control group
Physical therapists will provide personalized aerobic exercise program prescriptions in the preparatory period based on the results of exercise-related assessments, and the training intensity is based on the results of the maximum exercise test, with moderate intensity for 24 weeks, >=3 cardio workouts per week.
No change in exercise habits and maintaining baseline physical activity.