Effects of 6-month of Treatment With TRPV1 and TRPA1 Agonists in Older Patients With OD
Oropharyngeal Dysphagia, Swallowing Disorder
About this trial
This is an interventional treatment trial for Oropharyngeal Dysphagia focused on measuring TRP agonists, Sensory stimulation, Rehabilitation
Eligibility Criteria
Inclusion Criteria: ≥70 years With a positive Volume-Viscosity Swallow Test for oropharyngeal dysphagia Penetration-aspiration scale >1 in videofluoroscopy Able to follow the protocol and to give written informed consent. Exclusion Criteria: Life expectancy < 3m or palliative care Allergy to iodinated contrast or to the components of the treatment solutions Cancer or active infection Implanted electronic device Epilepsy Metal in the head Participation in another clinical trial (previous month).
Sites / Locations
- Hospital de Mataró
Arms of the Study
Arm 1
Arm 2
Arm 3
Active Comparator
Active Comparator
Placebo Comparator
Capsaicin
Piperine
Placebo
Natural TRPV1 agonist at a concentration of 10mcM. Posology: 10 mL every 8h for 6 month.
Natural TRPA1/V1 agonist at a concentration of 150mcM. Posology: 10 mL every 8h for 6 month.
Deionized water + the same preservatives as in the active treatments