Impact of Continuous Positive Airway Pressure on the Occurrence of Acute Exacerbations of COPD in Patients With COPD-OSA Overlap Syndrome (CO-OS) (SLEEPOVEA)
Sleep Apnea, COPD Exacerbation, Overlap Syndrome
About this trial
This is an interventional treatment trial for Sleep Apnea focused on measuring sleep apnea, copd, overlap syndrome
Eligibility Criteria
Inclusion Criteria: 40 years of age or older Grade of 2 or higher on the modified Medical Research Council scale (which ranges from 0 to 4, with higher grades indicating more severe dyspnea) A post-bronchodilator forced expiratory volume in 1 second (FEV1) of less than 70% of the predicted value, and a postbronchodilator ratio of FEV1 to forced vital capacity (FVC) of less than 0.70. Documented history of at least one moderate or severe COPD exacerbation during the previous year Clinical suspicion of OSA (based on a STOP-bang questionnaire >3), Have a telephone or a tablet or accept to use one during the study, Willing and able to comply with all study procedures, Subjects covered by or having the rights to medical care assurance. An apnea-hypopnea index [AHI], ≥15 per hour based on a full night polysomnography and no significant central apneas (<5 central apneas per hour of sleep Exclusion Criteria: Severe daytime sleepiness (Epworth sleepiness Scale >14/24 and/or frequent sleepiness while driving or patient escaping a sleep-onset accident within the last 12 months), Severe unstable cardiovascular disease (heart failure with FEVG≤45%, recurrent cardiac arrhythmia, instable coronary heart disease or stroke), Patient on long-term oxygen therapy or non-invasive ventilation Previously documented severe hypercapnia (PaCO2 ≥ 50mm Hg) Previously diagnosed and treated OSA Any rehabilitation program or any lung volume reduction procedure planned in the oncoming year Pregnancy, breastfeeding Bad understanding of the French language, Other protected person according to articles L1121.7 and L1121.8 of the French Public Health Act
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Experimental
No Intervention
CPAP group
Control group
Continuous positive airway pressure (CPAP) for one year
No CPAP treatment