BioClock: Bright Light Therapy for Depressive Disorders
Depression, Unipolar, Depression, Bipolar
About this trial
This is an interventional treatment trial for Depression, Unipolar focused on measuring Depression, Bright Light Therapy, Chronotherapy, Circadian Rhythm, Sleep, Life Style, Ecological Momentary Assessment, Actigraphy, Dim light melatonin onset, Response predictors
Eligibility Criteria
Inclusion Criteria: Age between 18 and 65. Diagnosis of unipolar or bipolar depression (seasonal or non-seasonal) as assessed with the Mini-International Neuropsychiatric Interview (M.I.N.I.) A current depressive episode (a score of 6 or higher on the Quick Inventory of depressive symptomatology Self Report (QIDS-SR) Sufficient knowledge of Dutch or English language to fill in questionnaires Provided Informed consent Exclusion Criteria: A current (hypo)manic or mixed episode (as assessed with the M.I.N.I.) Current psychotic episode (as assessed with the M.I.N.I.) Prominent active suicidality (score 10 or higher on the M.I.N.I. module) Antidepressant therapy (medication, psychotherapy or BLT, or other forms of specific treatments for depression) that started less than 2 months prior to study entry participants with bipolar disorder should be in mood-stabilizing treatment for at least 1 month in a recommended dosage, Use of melatonin or agomelatine in the last month Current use of antibiotics Current use of light sensitivity increasing medication Travelled across more than 1 time zone during past month or during the treatment Travelled to sunny holiday locations/winter sports during past month pre-existing eye and skin disorders (retinitis pigmentosa, porphyria, chronic actinic dermatitis and sun-induced urticaria) Systemic disorders with potential retinal involvement (rheumatoid arthritis and systemic lupus erythematosus) Suffering from colour blindness (assessed by Ishihara colour plates) Participated in night shift work in the last three months (Retinal) blindness, severe cataract and glaucoma Light-induced migraine or epilepsy Pregnancy, or parents with a child younger than 18 months old
Sites / Locations
- GGzE - Mental Health Institute of Eindhoven and the Kempen
- Leids Universitair Behandel- en Expertise Centrum
Arms of the Study
Arm 1
Arm 2
Arm 3
Active Comparator
Experimental
Experimental
Light@Home
LightCafé
LightCafé+
Standard Care - BLT in the home environment
BLT will be administered in a specialized cafe, under the supervision of clinical staff, promoting lifestyle changes and social interaction.
Treatment will be identical to the second arm but now complemented with the use of blue-light blocking glasses in the evening and the adoption of personalized BLT timing based on sleep-wake patterns