Dimethyl Fumarate Treatment for Intracranial Unruptured Aneurysms.
Intracranial Aneurysm, Aneurysm, Brain, Inflammation Vascular
About this trial
This is an interventional treatment trial for Intracranial Aneurysm focused on measuring Dimethyl Fumarate, High resolution magnetic resonance
Eligibility Criteria
Inclusion Criteria: Male or female aged ≥18 years. Unruptured IA of ≥3mm identified on imaging (CT, MRI or digital subtraction angiography). Aneurysm wall enhancement identified by HR-VWI before treatment. Ability to understand the objective of the trial with provision of written informed consent. Exclusion Criteria: MRI contraindications (metallic implant, contrast allergy, claustrophobia, etc). Planned treatment of the aneurysm within 12 months. Current treatment with drugs that might have an anti-inflammatory effect (aspirin, statins, immunosuppressive drugs, etc.). Severely impaired liver or renal function. Retreatment of recurrent aneurysm. Pregnant or lactating women. Malignant diseases (liver disease, kidney disease, congestive heart failure, malignant tumours, etc.). Poor compliance.
Sites / Locations
- Beijing Neurosurgical Institute & Beijing Tiantan Hospital
Arms of the Study
Arm 1
Arm 2
Experimental
Placebo Comparator
Dimethyl fumarate
Placebo
dimethyl fumarate enteric capsule (the initial dose is 120 mg twice a day, and after 7 days, the dose will be increased to the maintenance dose of 240 mg twice a day, for 6 months)
placebo with the same appearance (color, taste, size, shape)