Quantitative analysis: analysis of FLAIR hypersignals number
Analysis of FLAIR hypersignals numbers (lesion load)
Quantitative analysis: analysis of FLAIR hypersignals volume
Analysis of FLAIR hypersignals volume
Qualitative analysis: analysis of central vein lesions
Identification and quantification of central vein lesions on SWI
Qualitative analysis: analysis of peripheral rim lesion
Identification and quantification of peripheral rim lesions on SWI
Quantitative analysis: measurement of mean diffusivity
measurement of the mean diffusivity using diffusion tensor analysis
Quantitative analysis: measurement of anisotropy fraction
measurement of anisotropy fraction using diffusion tensor analysis
Quantitative analysis: measurement of cerebral blood flow (CBF)
cerebral blood flow analysis on 3DPCASL
Changes in serum light chain neurofilament values
Changes in serum light chain neurofilament values in patients with RRMS patients according to the treatment line (high efficacy treatment vs. medium efficacy treatment)
Clinical assessment scale: relapses
Clinical assessment scales (absolute changes and reaching threshold values): Relapses
Clinical assessment scale: Expanded Disability Status Scale (EDSS)
The EDSS scale ranges from 0 to 10 in 0.5 unit increments that represent higher levels of disability. Scoring is based on an examination by a neurologist.
Clinical assessment scale: Computerized Speed Cognitive Test (CSCT)
" Computerized Speed Cognitive Test " (CSCT) provides screening for cognitive impairment in MS patients
Clinical assessment scale: Six-Minute Walk Test (6MWT)
Six-Minute Walk Test
Clinical assessment scale: 9-Hole Peg Test (9-HPT)
The 9-HPT is a brief, standardized, quantitative test of upper extremity function.
Clinical assessment scale: Timed 25-Foot Walk (T25-FW)
The T25-FW is a quantitative mobility and leg function performance test based on a timed 25-walk.
Quality of life scale: The 5-level EQ-5D questionnaire (EQ5D-5L)
EQ5D5L comprises five dimensions: mobility, self-care, usual activities, pain/discomfort and anxiety/depression. Each dimension has 5 levels: no problems, slight problems, moderate problems, severe problems and extreme problems. Lower score indicate better outcomes.
The questionnaire also includes a visual analog scale in which the patient quantifies his or her perception of quality of life using a score ranging from the worst imaginable state of health (0) to the best imaginable state of health (100).
Quality of life scale: The Brief Pain Inventory (BPI)
The Brief Pain Inventory (BPI) assesses the severity of pain and its impact on functioning.
Quality of life scale: DN4
The "Douleur Neuropathique 4 questions" questionnaire is a 4 questions questionnaire on neuropathic pain rating from 0 to 10; If the patient's score is 4/10 or more, the test is positive When the practitioner suspects neuropathic pain, the DN4 questionnaire is useful as a diagnostic tool.
Fatigue scale: Chalder Fatigue Scale
Chalder Fatigue Scale is a self-administered questionnaire for measuring the extent and severity of fatigue.
Fatigue scale: Modified Fatigue Impact Scale (MFIS)
Modified Fatigue Impact Scale (MFIS) provides an assessment of the effects of fatigue in terms of physical, cognitive, and psychosocial functioning.
Sleep scale: Epworth Sleepiness Scale (ESS)
The Epworth Sleepiness Scale (ESS) is used to assess daytime sleepiness.The ESS is a self-administered questionnaire with 8 questions. ESS score can range from 0 to 24. A global score greater than ten is diagnostic of excessive daytime sleepiness .
Depression scale: Beck Depression Inventory (BID)
The Beck Depression Inventory (BDI) contains 21 items and identifies symptoms and attitudes associated with depression.
Anxiety scale: Generalized Anxiety Disorder 7-Item Scale (GAD-7)
Generalized Anxiety Disorder 7-Item Scale measures seven anxiety symptoms.
Headaches scale: ef-ID Migraine
ef-ID Migraine guide towards the diagnosis of migraine
Exploratory criteria:Serum Glial Fibrillary Acidic Protein (GFAP)
Serum GFAP
Exploratory criteria: Pittsburgh Sleep Quality Index (PSQI) questionnaire
Evaluation of habitual sleep quality trough a validated questionnaire. 19 items where each item is weighted on a 0-3 interval scale. The global PSQI score is then calculated by totaling the seven component scores, providing an overall score ranging from 0 to 21, where lower scores denote a healthier sleep quality.
Exploratory criteria: Idiopathic Hypersomnia Severity Hypersomnia Scale (IHSS)
Patient-reported questionnaire assessing the severity of excessive sleepiness, prolonged sleep duration, cognitive impairment and sleep inertia. The total score ranges from 0 to 50, with higher scores indicating more severe symptoms.
Exploratory criteria: RU SATED score
The Regularity, Sleep Quality, Alertness, Timing, Efficiency, Duration scale for sleep (RU SATED) ranges from 0 to 30, with higher scores indicating better sleep health.
Exploratory criteria: Insomnia Severity Index (ISI)
The Insomnia Severity Index is a seven item-scale scored on a five-point scale (from 0 to 4). The total score ranges from 0 to 28. Higher scores indicate more insomnia.
Exploratory criteria: Headaches Impact Test (HIT-6)
HIT-6 addresses six main domains affected by headaches, including pain, social functioning, role functioning, cognitive functioning, vitality and psychological stress.
Little or no impact: 49 or less ; some impact: 50-55 ; substantial impact: 56-59 ; severe impact: 60-78
Exploratory criteria: Godin Leisure-Time Exercise Questionnaire (GLTEQ)
Godin Leisure-Time Exercise Questionnaire (GLTEQ)