The Intervention of Psychobiotics in Patients With Anxiety Disorders
Anxiety Disorders
About this trial
This is an interventional supportive care trial for Anxiety Disorders focused on measuring anxiety, microbiota, psychobiotics
Eligibility Criteria
Inclusion Criteria: Age 20~65 years old Patients perceived that they had anxiety-related complaints, or with any type of anxiety disorders of adjustment disorders referred from the Departments of Psychiatry, Neurology, Internal Medicine, and Family Medicine in Mackay Memorial Hospital. Adult GAD-7 ≥ 8 points (to screen for generalized anxiety disorder) or a DSM-5 diagnosis of generalized anxiety disorder (F41.1) or unspecified anxiety disorder (F41.9) Those who are currently under the treatment of selective serotonin reuptake inhibitors (SSRI) will only be included if their SSRI treatment has been stable or has not been changed for 4 weeks. Exclusion Criteria: Have taken antibiotics or are receiving antibiotic treatment within one month. Have used probiotic products in powder, capsule or tablet form within two weeks (excluding yogurt, Yakult and other related foods). Patients who have undergone hepatobiliary gastrointestinal surgery (except for colorectal polypectomy and appendectomy). Past or current patients with inflammatory bowel disease. Those with a history of cancer. Those who are allergic to lactic acid bacteria products. Patients with severe depression (Patient Health Questionnaire-9 (PHQ-9) ≧ 20 points), or possible neurocognitive impairments (Mini-Mental States Examination (MMSE)<20), or those that had suicidal ideation noted on item 9 from PHQ-9. Patients with chronic psychiatric diseases who are currently taking drugs to treat acute diseases, organic brain diseases, or newly diagnosed or changed drugs within three months. Those who are receiving parenteral nutrition. Those who are evaluated by the principal investigator to be unsuitable to participate in the research.
Sites / Locations
- Mackay Memorial HospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Placebo Comparator
Heat-treated PS23
Placebo
Lactobacillus paracasei PS23 heat-treated
microcrystalline cellulose