Evaluation the Efficacy Between Botox Injection and Combination Pharmacotherapy in Patients With Detrusor Overactivity
Urinary Bladder, Overactive, Urodynamics, Effect of Drug
About this trial
This is an interventional treatment trial for Urinary Bladder, Overactive focused on measuring Detrusor overactivity, Urodynamic study, Combined pharmacotherapy, Botulinum Toxins, Effectiveness
Eligibility Criteria
Inclusion Criteria: Patients with detrusor overactivity which defined as a urodynamic observation characterized by involuntary detrusor contractions during the filling phase. Those who were refractory to monotherapy with either anti-muscarinics or β3-adrenoceptor agonists were enrolled for prospective study Exclusion Criteria: Postvoid urine retention before treatment
Sites / Locations
- Mackay Memorial HospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Active Comparator
Experimental
Intradetrusor onabotulinumtoxinA injection
Combination pharmacotherapy
The toxin produced by Clostridium botulinum binds to the nerves endings and inhibits the muscular contractions, help to treat overactivity of the bladder muscles.
Combine Mirabegron and Solifenacin.