Role of Acetaldehyde in the Development of Oral Cancer

Inclusion Criteria: 21-45 years of age for alcohol drinkers Occasionally consume alcohol At least 1 drink per month for healthy volunteers At least 1 drink in the last 3 months for Fanconi anemia patients Meets one of the three criteria Healthy volunteer - ALDH2*1/1* homozygotes-not of Eastern Asian decent; Healthy volunteer - ALDH2*1/2* heterozygotes-of Eastern Asian decent and experience flushing when drinking Individual's with Fanconi anemia (FA). 18-45 years of age for non-drinkers Never consume alcohol/not had alcohol in the last 6 months Healthy volunteers. Non-smoker (smoked < 100 cigarettes in a lifetime) Exclusion Criteria: Pregnant or nursing Taking any medication or drug that might affect alcohol use and absorption or that might be affected by alcohol consumption Healthy volunteers who have taken any antibiotics in the last 3 months Currently consuming more than 21 drinks per week Have any history of alcohol or drug related problems Current or former tobacco/nicotine product(s) user Any regular use of tobacco/nicotine products or marijuana in the last year (cigarettes, e-cigarettes, cigars, pipes, smokeless tobacco) "Trying" or limited use of any nicotine products or marijuana in the last 1 month Active infection (influenza, cold, COVID, respiratory / sinus infection) - admission in the study will be delayed pending improved health Non-FA volunteers who have an unstable medical condition or condition that could be affected by alcohol consumption (insulin-dependent diabetes, ulcers, heart issues) Experience severe adverse events (nausea, blacking out) when consuming even low doses of alcohol