A Clinical Study to Evaluate the Efficacy and Safety of Subcutaneous JS005 Injection in the Treatment of Adults With Moderate to Severe Chronic Plaque Psoriasis
Moderate to Severe Chronic Plaque Psoriasis
About this trial
This is an interventional treatment trial for Moderate to Severe Chronic Plaque Psoriasis
Eligibility Criteria
Inclusion Criteria: Subjects voluntarily particpate in this clinical study and sign the informed consent form. Male and female patients aged 18-75 years at the time of screening (both inclusive). Fertile female subjects must be willing to use a highly effective contraceptive method during the study period and 20 weeks (expected 5 half-lives) after the last study drug administration and have a negative pregnancy test during the screening period and prior to randomization. Exclusion Criteria: Pregnant and lactating women. A history of inflammatory bowel disease or other conditions with a high risk of perforation (e.g., severe gastrointestinal ulcers, etc.) or with other active autoimmune diseases (e.g., systemic lupus erythematosus, Sarcoidosis, etc.). Have a type of psoriasis other than chronic plaque psoriasis (e.g., pustular, erythrodermic, and guttate psoriasis), drug-induced psoriasis, or have an active inflammatory skin disease other than psoriasis Use of phototherapy, including but not limited to ultraviolet A phototherapy (with or without psoralens), ultraviolet B phototherapy, or excimer laser within 4 weeks prior to randomization. Subjects are unwilling to avoid excessive sunlight exposure within 4 weeks prior to randomization and during the study period; A (current) history of systemic infection or serious infection requiring hospitalization and/or intravenous anti-infective therapy (e.g., antibiotics, antifungal agents, antiviral agents) within 12 weeks prior to randomization; a history of any active infection, other than common upper respiratory infections, within 2 weeks prior to randomization;
Sites / Locations
- The First Affiliated Hospital of Bengbu Medical College
- The Second Affiliated Hospital of Anhui Medical University
- Beijing Friendship Hospital, Capital Medical University
- Beijing Tongren Hospital Affiliated to Capital Medical University
- China-Japan Friendship Hospital
- Peking University People's Hospital
- Peking University Third Hospital
- Ningbo Huamei Hospital, University of Chinese Academy of Sciences
- The First Affiliated Hospital of Chongqing Medical University
- The First Affiliated Hospital of Fujian Medical University
- The Second Affiliated Hospital of Xiamen Medical College
- Lanzhou University Second Hospital
- Dongguan People's Hospital
- Guangdong General Hospital
- Dermatology Hospital of Southern Medical University
- Guangzhou First People's Hospital
- Sun Yat-sen Memorial Hospital, Sun Yat-sen University
- Shenzhen People's Hospital
- The Affiliated Hospital of Chengde Medical College
- The First Hospital of Hebei Medical University
- Xingtai People's Hospital
- Nanyang city first People's Hospital
- The First Affiliated Hospital of Xinxiang Medical College
- Jingzhou Central Hospital
- Shiyan City People's Hospital
- Wuhan University People's Hospital
- The Second Xiangya Hospital, Central South University
- Xiangya Third Hospital, Central South University
- Lianyungang First People's Hospital
- The First Affiliated Hospital of Soochow University
- Wuxi Second People's Hospital
- Yancheng First People's Hospital
- Affiliated Hospital of Jiangsu University
- The First Affiliated Hospital of Gannan Medical College
- Jiangxi Dermatology HospitalRecruiting
- The Second Affiliated Hospital of Nanchang University
- Bethune First Hospital of Jilin University
- Panjin Liao oil precious stone flower hospital
- Shengjing Hospital affiliated to China Medical University
- Shenyang Hospital of Integrated Chinese and Western Medicine
- North East Central International Hospital Limited
- Baotou Central Hospital
- Inner Mongolia Baotou Steel Hospital
- Ningxia Medical University General Hospital
- Shandong Dermatology Hospital
- Jinan Central Hospital
- Shanghai Dermatology Hospital
- The Second Hospital of Shanxi Medical University City:Taiyuan
- The First Affiliated Hospital of Xi 'an Jiaotong University City:Xian
- Medicine School of Xi'an Jiaotong University
- Chengdu Second People's Hospital
- West China Hospital of Sichuan University
- Suining Central Hospital
- Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital
- The Second Affiliated Hospital of Kunming Medical University
- Hangzhou Third People's Hospital
- Hangzhou First People's Hospital
- Zhejiang Provincial People's Hospital
- Run Run Shaw Hospital, Zhejiang University School of Medicine
- The First Hospital of Jiaxing
- The First Affiliated Hospital of Wenzhou Medical University
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Experimental
Placebo Comparator
JS005 150mg (recombinant humanized monoclonal antibody against IL-17A)
JS005 300mg (recombinant humanized monoclonal antibody against IL-17A)
Placebo