The Effect of Low-dose Interleukin-2 on the Immune Landscape of Human Atherosclerotic Plaques at Single Cell Resolution. (ELLIPSE)
TIA, Carotid Artery Plaque, Carotid Atherosclerosis
About this trial
This is an interventional basic science trial for TIA focused on measuring Interleukin-2, IL-2, TIA, Carotid Stenosis
Eligibility Criteria
Inclusion Criteria: Presence of carotid stenosis on either ultrasound or CT scan. Planned to undergo carotid endarterectomy. Exclusion Criteria: Autoimmune disease Any regular immunosuppressive treatment [Inhaled or topical steroids are permissible] Modified Rankin Scale score of ≥4 at screening Known active hepatic disease or alanine aminotransferase (ALT) > 2xULN Severe chronic kidney disease (defined as eGFR < 30 ml/min/1.73m2) Allergy or intolerance to aldesleukin Signs or symptoms of active infection History of human immunodeficiency virus (HIV), hepatitis B or C Current malignancy requiring active treatment Vaccine within 4 weeks prior to screening or plans for vaccination during study period Women of child-bearing potential and pregnancy Women who are breast-feeding Clinically relevant medical or surgical conditions that, in the opinion of the
Sites / Locations
- Addenbrookes Hospital
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Low dose interleukin-2
Control
Commercially available aldesleukin with a UK marketing authorisation will be used and will be initially prepared as per SmPC.
Standard of care treatment