Micropulsed Laser in Patients With Macular Oedema in Retinal Dystrophies
Macular Edema, Inherited Retinal Dystrophy, Laser Retinopathy
About this trial
This is an interventional treatment trial for Macular Edema focused on measuring Visual Acuity, Retinal Function, IRD, Macular Edema
Eligibility Criteria
Inclusion Criteria: Patients with inherited retinal disease Age between 18 and 80 years Conclusive molecular genetic study for IRD Male or female patient Presence of macular oedema assessed by sd-OCT with reduction ≤ 20% after 3 months of diuretics or draining supplements or 4 months after last anti-VEGF or steroid injection Phakic and pseudophakic patients Central Retinal thickness > 320 microns in men and > 305 microns in women Informed consent freely granted and acquired before the start of the study Participant has the ability to understand and willingness to follow study instructions and is likely to complete all required visits and procedures. Exclusion Criteria: Patients with cataract extraction prior to 6 months Patients with IOP ≥ 20 mmHg Patients with a clinical diagnosis of retinal dystrophy of unproven genetic origin Patients with diabetes Patients with central serous chorioretinosis, retinal vein occlusion, age-related degeneration Patients with current or previous vitreo-retinal pathology or with indication for vitreo-retinal surgical therapy (tractional oedema) Patients with a lack of target fixation at 32 cm Pregnant women
Sites / Locations
- IRCSS Fondazione G:B:BiettiRecruiting
Arms of the Study
Arm 1
Experimental
inherited retinal dystrophies with macular oedema
Laser treatment will be performed in patients with macular edema in IRD (experimental arm) who: underwent treatment with diuretics or nutritional drainage products for 3 months and subsequent 'wash-out' of one month 17,18 and had no reduction in macular oedema, in terms of central retinal thickness, of at least 20% compared with the initial assessment they have had an intravitreal injection of anti-VEGF or steroids, and after 3 months there is no reduction in central retinal thickness (CRT) of at least 20% compared to the initial assessment have after 3 months a thickness reduction <10% compared to baseline assessment, following initial treatment with micropulsed laser, and may be candidates for repeating treatment; are not eligible for diuretic therapy due to the presence of comorbidities.