Comparing Oral Versus Parenteral Antimicrobial Therapy (COPAT)
Endovascular Infection, Bone and Joint Infection, Skin and Soft Tissue Infection
About this trial
This is an interventional treatment trial for Endovascular Infection focused on measuring COpAT, Oral antimicrobial therapy, OPAT, Parenteral antimicrobial therapy, Intravenous antimicrobial therapy
Eligibility Criteria
Inclusion (must meet all of the following): English speaking The patient is hospitalized at J.W. Ruby Memorial Hospital, United Hospital Center, Berkeley Medical Center, Wheeling Hospital, or Camden Clark Medical Center The patient has been diagnosed with ≥1 of the following: endovascular, bone and joint, skin and soft tissue, pulmonary, gastrointestinal, or genitourinary infection The patient is being transitioned to 2-8 weeks of IV antibacterial therapy on hospital discharge The patient has capacity to participate in routine OPAT/COpAT follow-up (telephone check-ins, laboratory monitoring, and in-person or telemedicine ID Clinic follow-up) Exclusion (may not meet any of the following): The patient is not appropriate for OPAT (active injection drug use, lack of infusion resources, and/or unstable outpatient environment) The patient is not appropriate for COpAT (unable to receive PO medication or lack of an effective PO antimicrobial option based on susceptibility testing) The patient is unable to give informed consent The patient is a prisoner, pregnant, and/or mentally handicapped The patient is determined unsafe for enrollment at the primary team's discretion
Sites / Locations
- West Virginia University
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Group 1 (Experimental)
Group 2 (Control)
COpAT (oral antimicrobial therapy) on hospital discharge
Standard of care (IV antimicrobial therapy) on hospital discharge