Safety of Use and Efficacy of Pandora for Patients Suffering From Gonarthrosis (PANDORA2) (PANDORA2)

Inclusion Criteria : Patient aged between 35 and 85 years. Body mass index (BMI) < 35 kg.m2. Medial or lateral femoro-tibial knee osteoarthritis, diagnosed according to the American College of Rheumatology criteria, radiological stage 2 and 3 according to the Kellgren-Lawrence criteria modified by Felson on an X-ray, of the knee in extension, less than 6 months old. Knee osteoarthritis responsible for walking pain in the target knee, assessed between 4 and 8 inclusive on an 11 points numerical scale (0 = none to 10 = extreme). Unilateral or bilateral knee osteoarthritis if the walking pain in the contralateral knee is < 3 based on 11 points numerical scale (0-10). Ambulatory patient able to walk 50 meters without a cane, crutch or walker. Patient giving his informed consent. Patient agreeing to follow-up study visits. Patient affiliated to the health social security system or beneficiary of such plan. Patient requiring viscosupplementation according to the investigator. Exclusion Criteria : Patient presenting knee osteoarthritis without impingement joint space narrowing of the femoro-tibial compartment (modified Kellgren stage 0-1) or with complete impingement joint space narrowing on the knee weight-bearing radiograph in extension (modified Kellgren stage 4). Patient with bilateral symptomatic gonarthrosis with walking pain of contralateral knee > 3. Patient with stage 4 patello-femoral osteoarthritis associated with femoro-tibial osteoarthritis. Patient with a flare of osteoarthritis of the target or contralateral knee. Patient who received viscosupplementation or Platelet Rich Plasma (PRP) injection, in the target knee, in the 6 months prior to inclusion. Patient who received an intra-articular injection of corticosteroids in the target knee in the 2 months prior to inclusion. Patients with a skin condition or a wound next to or near the injection site. Patients refusing to discontinue treatment with NSAIDs or cox-2 inhibitors during the follow-up period. Patient receiving treatment with level III analgesics (strong opioids). Patients receiving treatment with diacerhein, avocado and soy unsaponifiables, glucosamine or chondroitin initiated less than 2 months prior to inclusion. Patient with hypersensitivity to hyaluronic acid or tranexamic acid. Patient with a history of seizures. Patient who had arthroscopy of the target knee or major trauma to the target knee during the 3 months preceding inclusion. Patient scheduled to undergo surgery, for any cause, of the target knee or other joint of the lower limbs, planned within 6 months of inclusion, likely to interfere with follow-up or evaluation of the patient in the study. Patient with Fibromyalgia. Patient with an active neurological or vascular musculoskeletal disorder (such as rheumatoid arthritis, lupus, psoriatic arthritis, spondyloarthritis or any other autoimmune disease, Paget's disease, gout, coxopathy, tendinopathy of the lower limb, sciatic or crural radiculalgia) which, in the opinion of the investigator, would be likely to disrupt regular monitoring and/or interfere with the measurement of evaluated knee treatment efficacy. Patient with serious hemostasis disorders, venous or lymphatic stenosis of the lower limbs, history of thromboembolic disease - phlebitis or pulmonary embolism - or a high risk of thromboembolism. Patients with renal insufficiency. Patients with all evolving general condition as cardiac, digestive, endocrine, haematological or broncho-pulmonary which, in the opinion of the investigator, would be likely to disrupt regular monitoring and/or interfere with the measurement of evaluated knee treatment efficacy. Breastfeeding patient, pregnant or wishing to be during the 12 months of the study. Patients of childbearing age, sexually active without contraception. Patients unable to give personal consent. Patients participating or having participated in interventional research and whose follow-up ended within 2 months prior to inclusion.