Elemental Diet and Gut Microbiome
Irritable Bowel Syndrome
About this trial
This is an interventional other trial for Irritable Bowel Syndrome
Eligibility Criteria
Inclusion Criteria: • Participant must be able to understand and provide informed consent Males and Females ≥18-85 Female subjects of childbearing potential must have a negative pregnancy test upon study entry Female (and male) subjects with reproductive potential, must agree to use FDA approved methods of birth control for the duration of the study Subject self-reports experiencing SIBO symptoms within 30 days Positive (abnormal) lactulose breath test for SIBO on visit 1 (day -7) as defined as: Rise of hydrogen ≥ 20ppm within 90 minutes on LBT OR A methane level ≥10 ppm at any point during the 120-minute LBT Exclusion Criteria: • Inability or unwillingness of a participant to give written informed consent or comply with study protocol Pregnancy or lactating Type 1 or type 2 diabetes Active or ongoing infection that requires antibiotics other than the participants known prophylactic medications (i.e. active infection or antibiotic use in the last 1 month) Any condition that, in the opinion of the investigator, contraindicates participation in this study will be excluded from study participation. History of known Phenylketonuria (PKU) disease Non-English-speaking participants
Sites / Locations
- Cedars-Sinai Medical CenterRecruiting
Arms of the Study
Arm 1
Experimental
elemental diet
subjects will be using the elemental diet packets daily. Subjects who are positive for excessive methane (i.e. methane level>10 ppm) will be required to complete a single daily fasting methane measurement (SMM) for the duration of the 14 days.