Cognitive Improvement After Carotid Stenting in Hyperbaric Oxygen Therapy Trial

Inclusion Criteria: Age from 18 to 75 years Ischemic stroke or transient ischemic attack (TIA) occurred within 30 days before endovascular stent treatment National Institute of Health stroke scale (NIHSS) ≤3 Culprit vessel was the common carotid artery or extracranial internal carotid artery, involving or not involving the external carotid artery The degree of culprit arterial stenosis is 70-99 % ; based on Digital subtraction angiography (DSA) (According to North American Symptomatic Carotid Endarterectomy Trial (NASCET) method) The diameter of the target vessel between 4.0 mm - 9.0 mm Mini-mental State Examination (MMSE) score : education level-middle school ≤ 24; education level-high school ≤ 20 ; education level-college ≤ 17 Baseline modified Rankin Scale (mRS) score ≤ 3 Patient understands the purpose and requirements of the study, and has provided informed consent Exclusion Criteria: Tandem extracranial or intracranial stenosis (70%-99%) or occlusion that is proximal or distal to the target intracranial lesion Serious perioperative complications affecting subsequent hyperbaric oxygen therapy (such as cerebral hemorrhage, disabling stroke, etc.) Any history of brain parenchymal or subarachnoid, subdural or extradural haemorrhage in the past 12 months Hemorrhagic transformation after ischemic stroke within 60 days before enrollment Intracranial artery stenosis caused by non-atherosclerotic lesions, including: arterial dissection, Moyamoya disease, vasculitis disease, herpes zoster, varicella-zoster or other viral vascular diseases, neurosyphilis, any other intracranial infections, any intracranial stenosis related to cerebrospinal fluid cells, radiation-induced vascular disease, fibromuscular dysplasia, sickle cell disease, neurofibromatosis, central nervous system benign vascular disease, postpartum vascular disease, suspected vasospasm, suspicious embolism recanalization, etc Nervous system diseases in the past two years, characterized by transient or fixed neurological deficits (such as partial or secondary generalized seizures of epilepsy, complex or classic migraine, tumor or other intracranial space-occupying lesions, subdural hematoma, brain contusion or other post-traumatic lesions, intracranial infection, demyelinating diseases, intracranial hemorrhage, etc.), which cannot be distinguished from cerebral infarction History of stenting of an intracranial or extracranial artery Presence of any unequivocal cardiac source of embolism Chronic atrial fibrillation; paroxysmal atrial fibrillation or paroxysmal atrial fibrillation in the past 6 months, or a history of paroxysmal atrial fibrillation, requiring long-term anticoagulation Myocardial infarction in the past 30 days Combined with intracranial tumor, aneurysm or intracranial arteriovenous malformation Cannot tolerate dual antiplatelet therapy due to known diseases (such as gastrointestinal bleeding) Contraindications to heparin, aspirin, clopidogrel, ticagrelor, anesthesia, or contrast agents Hemoglobin<100g/L, platelet count <100×109/L, international normalized ratio (INR)>1.5, or heparin-related thrombocytopenia or uncorrectable factors leading to bleeding Not suitable for vessel angiography or endovascular interventional therapy (such as morbid obesity; serious vascular tortuosity that hinders the safe introduction of the guiding catheter) Severe hepatic and renal dysfunction Major surgery within the past 30 days or planned within 90 days Renal artery, iliac artery, and coronary artery requiring simultaneous intervention Life expectancy <1 year Pregnant or lactating women Cognitive assessment and follow-up could not be completed due to factors such as severe aphasia, neuropsychological illness or mental illness or dysarthria and inability to communicate History of drug or alcohol abuse, head trauma or central nervous system infection; current use of drugs that affect cognition Combined with diseases that are not suitable for hyperbaric oxygen therapy (such as untreated pneumothorax, uncontrolled epilepsy, claustrophobia, angle-closure glaucoma, cavitary pulmonary tuberculosis, etc.) Enrollment in another study that would conflict with the current study