Effects of Exogenous Ketosis on Renal Function, Renal Perfusion, and Sodium Excretory Capacity in Healthy Subjects (KETO)
Ketosis, Ketonemia
About this trial
This is an interventional basic science trial for Ketosis focused on measuring Kidney circulation, Kidney physiology, Kidney function, Glomerular Filtration Rate
Eligibility Criteria
Inclusion Criteria: BMI < 30 kg/m2 Safe contraception if women in childbearing age Normal biochemical screening Exclusion Criteria: Pregnancy or breast feeding Major heart-, liver-, kidney-, lung-, neurological- or endocrine disease Daily use of prescription drugs (expect for contraceptives) Alcohol or drug abuse Periodic fasting Routinely intake of ketogenic diet
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Active Comparator
Active Comparator
KetoneAid KE4, then Placebo drink
Placebo drink, then KetoneAid KE4
For five days each subject will receive beta-hydroxybutyrate (KE4), then crossed over to receive placebo drink for 5 days.
For five days each subject will receive a placebo drink three times daily, then subjects are crossed over to receive beta-hydroxybutyrate (KE4).