Remote Ischemic Conditioning for Stroke-associated Pneumonia (RICA-2)

Inclusion Criteria: Age≥18 years old; Diagnosis of acute ischemic stroke; Remote ischemic conditioning or sham-remote ischemic conditioning can be treated within 24 hours after stroke onset NIHSS score≥4; Subject or his or her legally authorized representative was able to provide informed consent. Exclusion Criteria: During the screening period, body temperature ≥ 38 ℃; Evidence of lung infection, urinary tract infection or other infectious diseases during the screening period Expected lifespan less than 7 days Mechanical ventilation is expected to be required within 7 days; Anti-infective drug were used within 7 days prior to stroke; Uncontrolled hypertension with medication (defined as systolic blood pressure ≥200 mmHg and/or diastolic blood pressure ≥110 mmHg); There are contraindications for remote ischemic conditioning (such as skin and soft tissue injury, fractures, peripheral arterial disease, etc. in the upper limbs); History of autoimmune disease or malignancies; Use of immunosuppressive drug within the preceding 3 months; Pregnant or lactating, or pregnancy test positive; Current participation in another investigational trial; Other conditions are not suitable for this trial as evaluated by researchers.