A Comparative Absorption Study of Various Iron Salts Supplements
Iron Deficiency, Iron Deficiency Anemia
About this trial
This is an interventional treatment trial for Iron Deficiency
Eligibility Criteria
Inclusion Criteria: Outpatients Age: 18 - 45 years, both gender Haemoglobin level < 12 g/dL Serum ferritin levels < 30 µg/L. Transferrin Saturation (TSAT) < 20 % Able to provide informed written consent. Able to adhere to the study protocol and willing to cooperate with the study investigators. Exclusion Criteria: Other causes of anaemia, apart from iron deficiency. Pregnant or lactating women, or women intending to become pregnant during the study. Administration of any iron-containing drugs during the last 3 months. History of erythropoietin drugs administration. People with cancer, chronic liver disease, chronic kidney disease, HIV, cardiovascular disease, pulmonary disease, mental health disorder, inflammatory disease such as IBD, any GI disease or disorder likely to affect the nutritional intestinal absorption. Subjects on Antacids (aluminium, calcium, magnesium preparations), anti-inflammatory drugs (NSAIDs, salicylates), antibiotic medications (aminoglycosides), cholesterol lowering medication (Bile acid-sequestrants), Ulcer medication (histamine H2 Antagonists), PPIs etc. Concomitant diseases and conditions, which, in the investigator's opinion, pose risk to a subject's safety in case of his/her participation in the study, or able to affect the safety data analysis in case of exacerbation of this disease/condition during the study. Hypersensitivity to iron therapy (both Oral and/or IV administration) and other components of the study drugs. Hormone therapy (including the use of androgens/anabolic steroids) or administration of drugs that inhibit blood formation, less than 3 months before the start of the study. History of severe allergic reactions or drug intolerance. Blood donation / blood transfusion within 30 days prior to screening or planned blood transfusion at time of screening.
Sites / Locations
- Bilawal Medical College HospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Experimental
Experimental
Experimental
Active Comparator
Intervention Arm B
Intervention Arm C
Interventional Arm D
Control Arm
Subjects in this arm will receive a daily single dose of oral 30mg elemental iron supplement as Ferrous Sulphate for 6 weeks
Subjects in this arm will receive a daily single dose of oral 30mg elemental iron supplement as Ferric Pyrophosphate for 6 weeks
Subjects in this arm will receive a daily single dose of oral 30mg elemental iron supplement as Ferric Sodium Pyrophosphate for 6 weeks
Subjects in this arm will receive a daily single dose of oral Vitamin D (200 IU) supplement for 6 weeks