A Study of CCX168 in Japanese and Caucasian Healthy Adult Males

Inclusion Criteria: Japanese and Caucasian healthy males aged 20 to 45 years inclusive (at the time of obtaining informed consent); Body Mass Index (body weight [kg]/squared height [m^2]): 18.5 kg/m^2 or more and less than 25 kg/m^2 for Japanese males or between 18.5 and 29 kg/m^2 for Caucasian males (at the time of screening visit); Body weight: 50 kg or more and less than 90 kg (at the time of screening visit). Exclusion Criteria: Participants with any abnormal findings (e.g., clinical laboratory test values outside the reference range) during the physical examination and other tests (vital signs, 12-lead ECG and clinical laboratory tests) that are judged by the principal investigator or subinvestigator to be clinically significant; Participants who test positive for immunological tests (hepatitis B surface antigen, hepatitis C virus antibody, serological reaction of syphilis, and human immunodeficiency virus antigen and antibody); Participants with a history of drug allergy; Participants who are a habitual alcohol drinker with an average pure alcohol intake of over 40 g/day; Participants who test positive for abuse of phencyclidines, benzodiazepines, cocaine, stimulants, cannabis, morphine, barbiturates, and tricyclic antidepressants during urine drug testing; Male participant who do not agree to use adequate contraception for a period from a start of the investigational product administration to 12 weeks after the final administration of the investigational product; Participants with a QTcF intervals of 450 msec or greater in the 12-lead ECG at the time of the screening visit and/or Day -1; Participants who consumed tobacco or a nicotine patch/gum within 12 weeks prior to the investigational product administration; Participants who received other prescription medications or over-the-counter medications (including vitamins and energy drinks) within 2 weeks prior to the investigational product administration (excluding topical formulation that is not expected systemic action); Participants who received any supplements (Saint John's wort [Hypericum perforatum] etc.) that have been reported to affect the pharmacokinetics of concomitant use of drugs within 2 weeks prior to the investigational product administration; Participants who received a grapefruit and an orange that contain the component inhibiting CYP3A4 or the food and drink containing these fruits within 1 week prior to the investigational product administration; Participants who received other investigational products within 16 weeks prior to the investigational product administration; Participants who donated more than 200 mL of blood (donation of whole blood, plasma components or platelets, etc.) within 4 weeks or more than 400 mL within 16 weeks prior to the investigational product administration; Participants who performed excessive exercise with symptoms of fatigue or muscle pain within 1 week prior to the investigational product administration; Participants who are judged by the principal investigator or subinvestigator as inappropriate for inclusion in this study.