Dexamethasone at Night vs at Induction on PONV After Laparoscopic Cholecystectomy
Postoperative Nausea and Vomiting, Postoperative Pain, Laparoscopic Cholecystectomy
About this trial
This is an interventional prevention trial for Postoperative Nausea and Vomiting
Eligibility Criteria
Inclusion Criteria: all consecutive adults (older than 18 years) with ASA physical status I-III undergoing elective laparoscopic cholecystectomy surgery at gastrointestinal surgery center. Exclusion Criteria: patient refusal use of steroids or antiemetic agents within 1 week of surgery chronic opioid therapy history of allergy to any study medications serum creatinine > 1.4 mg/dl liver enzymes more than triple normal limits pregnancy psychiatric or neurologic diseases or socioeconomic status that would hinder postoperative quality of recovery questionnaire Patients whose laparoscopic surgery is converted to open surgery after enrollment will be excluded.
Sites / Locations
- Faculty of MedicineRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
At-night dexamethasone
At-induction dexamethasone
Patients in the intervention group will receive intravenous 8 mg dexamethasone at night before surgery. The time of dexamethasone administration will be recorded. The dexamethasone ampule will be diluted in a 10 ml syringe and given in at least one minute to avoid unpleasant sensation in injection.
Patients in the control group will receive intravenous 8 mg dexamethasone just before or at the induction of anesthesia. The dexamethasone ampule will be diluted in a 10 ml syringe and given in at least one minute to avoid unpleasant sensation in injection.