Glucose-Guided Eating Pilot (GET CHARGED)
Postmenopausal, Prediabetes, Adolescent and Young Adult (AYA) Cancer Survivors
About this trial
This is an interventional prevention trial for Postmenopausal
Eligibility Criteria
Inclusion Criteria: All: Self-reported height and weight that is consistent with a BMI ≥ 27 kg/m2 Willing to use a continuous glucose monitor Own smartphone that is compatible with Dexcom CGM. Willingness to commute to GUMC for in-person study visits No active cancer (except for nonmelanoma skin cancer) Less than 5 lbs. weight change in previous 3 months Proficient in speaking and reading English Postmenopausal women with pre-diabetes: Age 18 years and older Diagnosed as having prediabetes. HbA1c (within 3 months) between 5.7% and 6.4% Postmenopausal (defined as reporting no menstrual period for ≥1 year or a reported history of a total abdominal hysterectomy with oophorectomy) AYA cancer survivors: Current age 21-39 years Previously diagnosed with cancer, with all cancer-related diagnosis chemotherapy and/or radiation completed at least 6 months previously Exclusion Criteria: Unable or unwilling to provide informed consent Clinical history of type 1 or type 2 diabetes Currently receiving anti-diabetics (e.g., insulin, GLP1), oral hypoglycemic agent (e.g., metformin), oral corticosteroids, oral glucocorticoids, beta blockers, hydroxyurea, atypical antipsychotic agents (i.e., Olanzapine, Aripiprazole) or systemic progestin-only contraceptives Current or past history of an eating disorder Self-identify as an overnight eater (defined as eating main meals between 9pm-5am) Have any contraindications for CGM, including: severe allergy to surgical adhesive, being on dialysis, receiving diathermy treatment, or scheduled CT scan or MRI during wear period Growth hormone deficiency, hypoadrenal function, or hypopituitary function
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
GGE with CGM
CGM only
Participants randomized to the Glucose-Guided Intervention will be trained to align their mealtimes with a personalized glucose threshold monitored using continuous glucose monitoring (CGM) and the GGE study app.
Participants randomized to the control arm will only wear a CGM.