Pre-sleep Protein Supplementation and Load Carriage Recovery in British Army Recruits
Primary Purpose
Protein-energy; Imbalance, Muscle Soreness
Status
Completed
Phase
Not Applicable
Locations
United Kingdom
Study Type
Interventional
Intervention
High protein intake
Moderate protein intake
Carbohydrate maltodextrin placebo
Control no supplementation
Sponsored by
About this trial
This is an interventional other trial for Protein-energy; Imbalance
Eligibility Criteria
Inclusion Criteria: Enrolled into British Army basic training Medically fit to train and complete the load carriage test Exclusion Criteria: Not taking any other nutritional supplement Pregnant
Sites / Locations
- Anglia Ruskin University
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm Type
Experimental
Experimental
Placebo Comparator
Other
Arm Label
High protein intake supplementation
Moderate protein intake supplementation
Carbohydrate placebo
Control group, no supplementation
Arm Description
A 60g daily dose of whey protein supplementation
A 20g dose of whey protein supplementation
An isocaloic maltodextrin carbohydrate placebo
Control group, not taking any supplementation, only completing basic training activities
Outcomes
Primary Outcome Measures
Change in lower body muscle function
The change in maximal vertical jump height in participants before and after the load carriage test
Secondary Outcome Measures
The change in urinary myoglobin
The relative change in concentration of urinary myoglobin (ng/ml) in participants before and after the load carriage test
The change in urinary 3-methylhistidine
The relative change in concentration of urinary 3-methylhistidine (nmol/ml) in participants before and after the load carriage test
The change in perceived muscle soreness
The relative change in perceived muscle soreness assessed via visual analogue scale
Full Information
NCT ID
NCT05998603
First Posted
August 3, 2023
Last Updated
August 11, 2023
Sponsor
Anglia Ruskin University
Collaborators
University of Exeter
1. Study Identification
Unique Protocol Identification Number
NCT05998603
Brief Title
Pre-sleep Protein Supplementation and Load Carriage Recovery in British Army Recruits
Official Title
Pre-sleep Protein Supplementation Does Not Improve Recovery From Load Carriage in British Army Recruits
Study Type
Interventional
2. Study Status
Record Verification Date
July 2023
Overall Recruitment Status
Completed
Study Start Date
May 1, 2021 (Actual)
Primary Completion Date
May 31, 2022 (Actual)
Study Completion Date
May 31, 2022 (Actual)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Anglia Ruskin University
Collaborators
University of Exeter
4. Oversight
Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
No
5. Study Description
Brief Summary
Load carriage is a common military activity and has been shown to induce acute exercise-induced muscle damage (EIMD) and impair muscle function. Protein supplementation can accelerate muscle recovery by attenuating EIMD and muscle function loss. This study investigated the impact of an additional daily bolus of protein prior to sleep throughout training on acute muscle recovery following a load carriage test in British Army recruits. Muscle function (maximal jump height), perceived muscle soreness and urinary markers of muscle damage were assessed before (PRE), immediately post (POST), 24-hours post (24h-POST) and 40-hours post (40h-POST) a load carriage test.
Detailed Description
British Army basic training (BT) is physically demanding with new recruits completing multiple bouts of physical activity each day with limited recovery. Load carriage is one of the most physically demanding BT activities and has been shown to induce acute exercise-induced muscle damage (EIMD) and impair muscle function. Protein supplementation can accelerate muscle recovery by attenuating EIMD and muscle function loss. This study investigated the impact of an additional daily bolus of protein prior to sleep throughout training on acute muscle recovery following a load carriage test in United Kingdom (UK) British Army recruits. A mixed group (men/women) over over 120 new recruits were randomised to dietary control (CON), carbohydrate placebo (PLA), moderate (20g; MOD) or high (60g; HIGH) protein supplementation. Muscle function (maximal jump height), perceived muscle soreness and urinary markers of muscle damage were assessed before (PRE), immediately post (POST), 24-hours post (24h-POST) and 40-hours post (40h-POST) a load carriage test. The underlying aim of this study was to assess whether additional protein intake could attenuate aspects of muscle damage from an acute load carriage test including muscle function, muscle soreness and biomarkers of muscle damage during short term recovery.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Protein-energy; Imbalance, Muscle Soreness
7. Study Design
Primary Purpose
Other
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
Participant
Allocation
Randomized
Enrollment
122 (Actual)
8. Arms, Groups, and Interventions
Arm Title
High protein intake supplementation
Arm Type
Experimental
Arm Description
A 60g daily dose of whey protein supplementation
Arm Title
Moderate protein intake supplementation
Arm Type
Experimental
Arm Description
A 20g dose of whey protein supplementation
Arm Title
Carbohydrate placebo
Arm Type
Placebo Comparator
Arm Description
An isocaloic maltodextrin carbohydrate placebo
Arm Title
Control group, no supplementation
Arm Type
Other
Arm Description
Control group, not taking any supplementation, only completing basic training activities
Intervention Type
Dietary Supplement
Intervention Name(s)
High protein intake
Intervention Description
The participants received a 60g whey protein bolus each evening prior to sleep pre and post a military load carriage test.
Intervention Type
Dietary Supplement
Intervention Name(s)
Moderate protein intake
Intervention Description
The participants received a 20g whey protein bolus each evening prior to sleep pre and post a military load carriage test.
Intervention Type
Dietary Supplement
Intervention Name(s)
Carbohydrate maltodextrin placebo
Intervention Description
The participants received an isocaloric carbohydrate bolus each evening prior to sleep pre and post a military load carriage test.
Intervention Type
Other
Intervention Name(s)
Control no supplementation
Intervention Description
Control group, no supplementation, only basic training
Primary Outcome Measure Information:
Title
Change in lower body muscle function
Description
The change in maximal vertical jump height in participants before and after the load carriage test
Time Frame
40-hours
Secondary Outcome Measure Information:
Title
The change in urinary myoglobin
Description
The relative change in concentration of urinary myoglobin (ng/ml) in participants before and after the load carriage test
Time Frame
40-hours
Title
The change in urinary 3-methylhistidine
Description
The relative change in concentration of urinary 3-methylhistidine (nmol/ml) in participants before and after the load carriage test
Time Frame
40-hours
Title
The change in perceived muscle soreness
Description
The relative change in perceived muscle soreness assessed via visual analogue scale
Time Frame
40-hours
10. Eligibility
Sex
All
Minimum Age & Unit of Time
18 Years
Maximum Age & Unit of Time
35 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria:
Enrolled into British Army basic training
Medically fit to train and complete the load carriage test
Exclusion Criteria:
Not taking any other nutritional supplement
Pregnant
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Justin D Roberts, PhD
Organizational Affiliation
Anglia Ruskin University
Official's Role
Principal Investigator
Facility Information:
Facility Name
Anglia Ruskin University
City
Cambridge
State/Province
Cambridgeshire
ZIP/Postal Code
CB1 1PT
Country
United Kingdom
12. IPD Sharing Statement
Plan to Share IPD
No
Learn more about this trial
Pre-sleep Protein Supplementation and Load Carriage Recovery in British Army Recruits
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