Therapeutic Ketogenic Diet in Anorexia Nervosa
Anorexia Nervosa in Remission
About this trial
This is an interventional treatment trial for Anorexia Nervosa in Remission
Eligibility Criteria
Inclusion Criteria: Provision of signed and dated informed consent form Stated willingness to comply with all study procedures and availability for the duration of the study Persons, aged 18 to 45 years History of anorexia nervosa according to DSM-5 criteria Weight recovered at the time of study inclusion (body mass index > 17.5 kg/m2) Greater or equal to 2 standard deviations scores of eating disorder-relevant behaviors on the Eating Disorder Inventory-3 and Eating Disorder Examination Questionnaire The following types of psychiatric medications are allowed: antidepressant, anxiolytic, atypical antipsychotic, mood stabilizers English is primary spoken language Exclusion Criteria: Pregnancy or lactation Electrolyte, blood count, kidney function or liver function abnormalities Psychosis Neurocognitive disorders including dementias or traumatic brain injury that is symptomatic Current alcohol use disorder (AUD) or substance use disorder (SUD) according to DSM-5 criteria Uncontrolled hypertension Hepatic impairment (Class-Pugh b or c) Diabetes mellitus Family history of porphyria History of recent heart attack, vascular disease, or any other current acute medical conditions as determined by the principal investigator Inability or unwillingness to adhere to the TKD diet for the duration of the study Blind or illiterate individuals
Sites / Locations
- University of California San DiegoRecruiting
Arms of the Study
Arm 1
Experimental
Therapeutic Ketogenic Diet
A 2-week therapeutic ketogenic diet (TKD) induction will be implemented to establish nutritional ketosis (the goal are BHB blood levels of 0.5-3.0 millimoles per liter [mmol/L]). After establishing the ketotic state, study participants will continue TKD for 12 weeks.