Hydroxycitrate: A Novel Therapy for Calcium Phosphate Urinary Stones
Calcium Phosphate Kidney Stones
About this trial
This is an interventional prevention trial for Calcium Phosphate Kidney Stones focused on measuring Urolithiasis, Calcium phosphate, Citrate, Acid-base
Eligibility Criteria
Inclusion Criteria: - Calcium Phosphate stone formers Exclusion Criteria: History of recurrent urinary tract infections Chronic diarrhea Estimated Glomerular Filtration Rate (eGFR) < 45 ml/min/1.73 m2 History of primary hyperparathyroidism Hypokalemia Hyperkalemia Pregnancy
Sites / Locations
- UT Southwestern Medical CenterRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Active Comparator
Experimental
Experimental
Placebo Comparator
Potassium Citrate (Urocit®-K)
Super CitriMax; OHCit-standard dose
Super CitriMax; OHCit-low dose
Placebo
Potassium Citrate KCit 10 mEq 2 tabs, twice daily and Placebo 1 tab, twice daily Total Daily Dose: Citrate 40 mEq/d
Super CitriMax 7 mEq 3 tabs, twice daily Total Daily Dose: OHCit 42 mEq/d
Super CitriMax 7 mEq 2 tabs, twice daily And Placebo 1 tab, twice daily Total Daily Dose: OHCit 28 mEq/d
Placebo 3 tablets twice daily Total Daily Dose: None