A Study to Evaluate the Efficacy, Safety, and Tolerability of BMS-986278 in Participants With Idiopathic Pulmonary Fibrosis
Idiopathic Pulmonary Fibrosis
About this trial
This is an interventional treatment trial for Idiopathic Pulmonary Fibrosis focused on measuring BMS-986278, LPA1 antagonist, IPF, Pulmonary fibrosis
Eligibility Criteria
Inclusion Criteria: Subjects with IPF aged ≥ 40 years at the time of signing the informed consent Diagnosis of IPF within 7 years prior to screening that is supported by centrally read chest high-resolution computed tomography (HRCT) obtained at screening and verification of usual interstitial pneumonia. If on pirfenidone or nintedanib, participants must have been on a stable dose for at least 90 days prior to screening If not currently on pirfenidone or nintedanib, participants must not have received either of these medications within 28 days prior to screening. Women who are of childbearing potential must have a highly effective form of contraception and must provide a negative urine/serum pregnancy test Men who are sexually active with women of childbearing potential agree to use male barrier contraception Exclusion Criteria: History of stroke or transient ischemic attack within 3 months prior to screening Significant cardiac disease within 6 months prior to screening per the investigator's discretion Participants who have a current malignancy or a previous malignancy in the past 5 years prior to screening, except for those who have a documented history of cured nonmetastatic squamous cell skin carcinoma, basal cell skin carcinoma, or cervical carcinoma in situ. Note: Other protocol-defined inclusion/exclusion criteria apply
Sites / Locations
- The University of Alabama at Birmingham
- Pulmonary and Sleep Associates of Jasper, P.C
- St. Joseph's Hospital and Medical Center
- Scripps Clinic Torrey Pines
- University of California San Diego
- University of Southern California (USC) - Keck School of Medicine (KSOM) - Transplant Clinic
- David Geffen School of Medicine at UCLA
- UC Irvine Medical Center
- University of California UC Davis Medical Center
- University of California, San Francisco Medical Center- Pulmonary Practice
- Stanford Hospital And Clinics
- University of Colorado Anschutz Medical Campus - Department of Family Medicine
- National Jewish Health
- Yale New Haven Hospital
- Christiana Care Pulmonary Associates - Newark
- Medstar Georgetown University Hospital
- Meris Clinical Research - Main Office
- Florida Lung, Asthma and Sleep Specialists - Celebration
- St Francis Sleep Allergy & Lung Institute
- Omega Research Consultants LLC
- Malcom Randall VA Medical Center
- University of Florida (UF) Health Shands Hospital
- Harmony Medical Research Institute, Inc
- Pulmonary Specialists of the Palm Beaches
- Bruce W. Carter Department of Veterans Affairs Medical Center
- Renstar Medical Research
- Avanza Medical Research Center
- Coastal Pulmonary & Critical Care, P.L.C.
- University of South Florida
- Cleveland Clinic Florida-Maroone Cancer Center
- Piedmont Healthcare - Piedmont Heart Institute
- Pulmonology, Sleep, Asthma & Allergy Center of Dublin
- Northwestern Memorial Hospital
- Rush University Medical Center - Rush Pulmonary and Critical Care Medicine - Professional Building
- The University of Chicago Medicine
- NorthShore University HealthSystem - NorthShore Research Institute
- Loyola University Health System
- Illinois Lung & Critical Care Institute
- Indiana University Health, Advanced Heart and Lung Care Center
- University of Iowa Hospitals and Clinics
- University of Kansas Medical Center (KUMC)
- Louisville Pulmonary Care
- Norton Healthcare, Inc.
- University of Maryland - Marlene and Stewart Greenebaum Cancer Center
- University of Maryland St. Joseph Medical Center
- Massachusetts General Hospital
- Brigham and Women's Hospital
- Steward St. Elizabeth Medical Center
- Baystate Pulmonary & Critical Care Medicine Springfield
- Spectrum Health Medical Group Pulmonary
- The Lung Research Center
- Washington University School of Medicine in St. Louis
- Newark Beth Israel Medical Center (NBIMC) - Barnabas Health Lung Center
- Icahn School of Medicine at Mount Sinai
- Lenox Hill Hospital Northwell Health
- Duke University Medical Center
- Accellacare US Inc. of Wilmington
- Salem Chest Specialists, P.A.
- University of Cincinnati College Of Medicine
- The Ohio State University Wexner Medical Center
- Infectious Disease Associates Of NW Ohio Inc - Toledo
- OU Health Sciences Center - OU Health Physicians - Cardiology, Pulmonary & Vascular Medicine Clinic
- Layrek Clinical ResearchRecruiting
- Oregon Health & Science University - Pulmonary Clinic
- Penn State Milton S. Hershey Medical Center
- Penn Medicine - Perelman Center for Advanced Medicine
- Thomas Jefferson University Hospital - Jane and Leonard Korman Lung Center
- Temple University Hospital (TUH) - Temple Lung Center (TLC)
- (UPMC) - Dorothy P. and Richard P. Simmons Center for Interstitial Lung Diseases (ILD)
- Pulmonology Assoicates - Wynnewood
- AnMed Health Oglesby Center - AnMed Health Pulmonary and Sleep Medicine
- Medical University of South Carolina- College of Medicine
- Clinical Research of Rock Hill
- Vanderbilt Lung Institute - One Hundred Oaks
- Ascension - Saint Thomas
- University of Texas Southwestern Medical Center - Pulmonary Specialty Clinic
- Baylor University Medical Center At Dallas
- Baylor College of Medicine Medical Center - Pulmonary, Critical Care, and Sleep Medicine
- McGovern Medical School - UT Physicians - Pulmonary Medicine - Texas Medical Center Location
- Metroplex Pulmonary and Sleep Center
- The University of Texas Health San Antonio Medical Arts & Research Center
- University of Utah, University Hospital
- Vcu Medical Center
- Western Washington Medical Group (WWMG) - Everett - Silver Lake Medical Center Location
- University of Washington Medical Center
- Froedtert & the Medical College of Wisconsin Froedtert Hospital
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- Alliance Pulmonary Group
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Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Experimental
Placebo Comparator
BMS-986278 Dose 1
BMS-986278 Dose 2
BMS-986278 Placebo