CSF Metabolomics and Glymphatic Function in Patients Receiving VP- Shunt Surgery.
The Association of Postoperative Cognitive Dysfunction With Glymphatic Function and Neuroinflammation, The Association of Postoperative Cognitive Dysfunction With CSF Metabolomic Change
About this trial
This is an interventional diagnostic trial for The Association of Postoperative Cognitive Dysfunction With Glymphatic Function and Neuroinflammation focused on measuring anesthesia depth monitoring, postoperative cognitive dysfunction, metabolomics, cerebrospinal fluid, glymphatic function
Eligibility Criteria
Inclusion Criteria: patients with communicating hydrocephalus for elective VP shunt surgery under general anesthesia age> 60 y/o conscious clear fluency in Chinese anticipated hospital stay ≥ 3 days after surgery Exclusion Criteria: unstable preoperative condition (unstable angina, CHF, asthma attack) within 4 weeks before surgery, severe hepatic dysfunction or renal failure history of neuropsychological diseases such as schizophrenia, Parkinson's disease, dementia, stroke, pre-op cognitive impairment, preoperative delirium, preoperative depression, allergy to contrast medium of MRI.
Sites / Locations
- Linkou Chang Gung Memorial HospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Experimental
No Intervention
BIS group
DEX group
Usual group
Use BIS monitoring to adjust intraoperative anesthetics.
use BIS monitoring to adjust anesthetics and give dexmedetomidine infusion.
usual care with 1 MAC sevoflurane maintainance.